Observational studyInternational journal of obesity (2005)2024
Impact of polygenic score for BMI on weight loss effectiveness and genome-wide association analysis.
Observational study in International journal of obesity (2005), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02829619 (Meal Timing, Genetics and Weight Loss in a Mediterranean Population), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Meal Timing, Genetics and Weight Loss in a Mediterranean Population
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Integrative Roles of Functional Foods, Microbiotics, Nutrigenetics, and Nutrigenomics in Managing Type 2 Diabetes and Obesity.Nutrients · 2025Pooled it
- Dietary intervention and BMI reduction in individuals at the extremes of genetic predisposition to higher BMI: a randomized controlled trial.Nature communications · 2026Trial
- Key Determinants of Weight Loss Trajectory Across Different Periods of a Behavioral Weight Loss Intervention.Obesity (Silver Spring, Md.) · 2026Trial
- Polygenic prediction of body mass index and obesity through the life course and across ancestries.Nature medicine · 2025Article
- Early meal timing attenuates high polygenic risk of obesity.Obesity (Silver Spring, Md.) · 2025Article
- Uncovering key factors in weight loss effectiveness through machine learning.International journal of obesity (2005) · 2025Observational
- Siesta behavior and genetics interact to influence obesity risk.Obesity (Silver Spring, Md.) · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
backgroundWhile environmental factors play an important role in weight loss effectiveness, genetics may also influence its success. We examined whether a genome-wide polygenic score for BMI was associated with weight loss effectiveness and aimed to identify common genetic variants associated with weight loss.
methodsParticipants in the ONTIME study (n = 1210) followed a uniform, multimodal behavioral weight-loss intervention. We first tested associations between a genome-wide polygenic score for higher BMI and weight loss effectiveness (total weight loss, rate of weight loss, and attrition). We then conducted a genome-wide association study (GWAS) for weight loss in the ONTIME study and performed the largest weight loss meta-analysis with earlier studies (n = 3056). Lastly, we ran exploratory GWAS in the ONTIME study for other weight loss outcomes and related factors.
resultsWe found that each standard deviation increment in the polygenic score was associated with a decrease in the rate of weight loss (Beta (95% CI) = -0.04 kg per week (-0.06, -0.01); P = 3.7 × 10
conclusionOur findings are expected to help in developing personalized weight loss approaches based on genetics. CLINICAL
trial registrationObesity, Nutrigenetics, Timing, and Mediterranean (ONTIME; clinicaltrials.gov: NCT02829619) study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.