Evidence map›Paper›PMID 38267413›Full record

ArticleNature communications2024

Tumour-retained activated CCR7

Colin Y C Lee, Bethany C Kennedy, Nathan Richoz, Isaac Dean, Zewen K Tuong, Fabrina Gaspal, Zhi Li, Claire Willis, Tetsuo Hasegawa, Sarah K Whiteside and 7 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
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  3. Review
  4. Review
  5. Article
  6. Article
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  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Identification of an Immunotherapy-Associated CD1cInternational journal of women's health · 2026
    Article
  18. Loss of SHP-1 in CD11cFrontiers in immunology · 2026
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Colin Y C LeeMolecular Immunity Unit, Department of Medicine, Medical Research Council Laboratory of Molecular Biology, University of Cambridge, Cambridge, UK.ORCID 0000-0001-8380-4917
Bethany C KennedyInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.ORCID 0000-0001-9529-7545
Nathan RichozMolecular Immunity Unit, Department of Medicine, Medical Research Council Laboratory of Molecular Biology, University of Cambridge, Cambridge, UK.
Isaac DeanInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.ORCID 0000-0002-4750-5335
Zewen K TuongMolecular Immunity Unit, Department of Medicine, Medical Research Council Laboratory of Molecular Biology, University of Cambridge, Cambridge, UK.
Fabrina GaspalInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Zhi LiInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.ORCID 0000-0002-0583-1116
Claire WillisInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Tetsuo HasegawaMolecular Immunity Unit, Department of Medicine, Medical Research Council Laboratory of Molecular Biology, University of Cambridge, Cambridge, UK.
Sarah K WhitesideDepartment of Pathology, University of Cambridge, Cambridge, UK.
David A PosnerMolecular Immunity Unit, Department of Medicine, Medical Research Council Laboratory of Molecular Biology, University of Cambridge, Cambridge, UK.
Gianluca CarlessoEarly Oncology R&D, AstraZeneca, Gaithersburg, MD, USA.
Scott A HammondEarly Oncology R&D, AstraZeneca, Gaithersburg, MD, USA.ORCID 0000-0001-5800-4328
Simon J DovediEarly Oncology R&D, AstraZeneca, Cambridge, UK.
Rahul RoychoudhuriDepartment of Pathology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-5392-1853
David R WithersInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK. d.withers@bham.ac.uk.ORCID 0000-0003-3757-7594
Menna R ClatworthyMolecular Immunity Unit, Department of Medicine, Medical Research Council Laboratory of Molecular Biology, University of Cambridge, Cambridge, UK. mrc38@medschl.cam.ac.uk.ORCID 0000-0002-3340-9828
MRC Laboratory of Molecular Biology · GBUniversity of Birmingham · GBAstraZeneca (United States) · USUniversity of Cambridge · GBAstraZeneca (United Kingdom) · GB

Funding

Cancer Research UK 27535Medical Research Council MC_UP_2201/2Wellcome Trust
6 · The paper itself

Abstract

Tumour dendritic cells (DCs) internalise antigen and upregulate CCR7, which directs their migration to tumour-draining lymph nodes (dLN). CCR7 expression is coupled to an activation programme enriched in regulatory molecule expression, including PD-L1. However, the spatio-temporal dynamics of CCR7

Indexed as

CD8-Positive T-LymphocytesNeoplasmsAnimalsAntigen PresentationDendritic CellsHumansMiceReceptors, CCR7CCR7 protein, humanReceptors, CCR7

Identifiers

PMID38267413
PMCPMC10808534
OpenAlexW4391169001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.