Evidence map›Paper›PMID 38266874›Full record

ArticleToxicology and applied pharmacology2024

Prenatal arsenite exposure alters maternal cardiac remodeling during late pregnancy.

Nicole Taube, Raihan Kabir, Obialunanma V Ebenebe, Haley Garbus, Sarah-Marie Alam El Din, Emily Illingworth, Michael Fitch, Nadan Wang, Mark J Kohr

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology and applied pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Gestational arsenite exposure alters maternal postpartum heart size and induces CaAmerican journal of physiology. Heart and circulatory physiology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Nicole TaubeDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Raihan KabirDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Obialunanma V EbenebeDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Haley GarbusDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Sarah-Marie Alam El DinDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Emily IllingworthDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Michael FitchDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Nadan WangCardiology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Mark J KohrDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. Electronic address: mkohr1@jhu.edu.
Johns Hopkins University · US

Funding

Traning Program in Environmental Health SciencesT32ES007141 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Marsha Wills-Karp · 1985 to 2026
$22.2M
S-nitrosation in cell survival and cell deathR01HL136496 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KOHR, MARK JEFFREY · 2018 to 2022
$2.0M
Role of formaldehyde, formate and one-carbon metabolism in the female heartR21HL157800 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KOHR, MARK JEFFREY · 2021 to 2022
$450k
Sex Differences in Endogenous Formaldehyde Production and One-Carbon Metabolism: Potential Links to CardioprotectionF31HL165820 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI GARBUS, HALEY CAITLIN · 2022 to 2023
$74k
NHLBI NIH HHS F31 HL165820NHLBI NIH HHS R01 HL136496NHLBI NIH HHS R21 HL157800NIEHS NIH HHS T32 ES007141
6 · The paper itself

Abstract

Exposure to inorganic arsenic through drinking water is widespread and has been linked to many chronic diseases, including cardiovascular disease. Arsenic exposure has been shown to alter hypertrophic signaling in the adult heart, as well as in utero offspring development. However, the effect of arsenic on maternal cardiac remodeling during pregnancy has not been studied. As such, there is a need to understand how environmental exposure contributes to adverse pregnancy-related cardiovascular events. This study seeks to understand the impact of trivalent inorganic arsenic exposure during gestation on maternal cardiac remodeling in late pregnancy, as well as offspring outcomes. C57BL/6 J mice were exposed to 0 (control), 100 or 1000 μg/L sodium arsenite (NaAsO

Indexed as

ArsenicArsenitesCardiovascular DiseasesPrenatal Exposure Delayed EffectsAnimalsFemaleHumansMaternal ExposureMiceMice, Inbred C57BLPregnancyReceptors, ProgesteroneVentricular RemodelingArsenicarseniteArsenitesReceptors, ProgesteroneArsenicCardiotoxicityCardiovascular diseaseMaternal exposurePregnancy

Identifiers

PMID38266874
PMCPMC10922692
OpenAlexW4391115782

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.