Evidence map›Paper›PMID 38266662›Full record

ArticleBrain, behavior, and immunity2024

Accelerated neurodegeneration of basal forebrain cholinergic neurons in HIV-1 gp120 transgenic mice: Critical role of the p75 neurotrophin receptor.

Andrew Speidell, Christy Agbey, Italo Mocchetti

Open access · greenAbstract read
In one paragraph

Article in Brain, behavior, and immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Andrew SpeidellInterdisciplinary Program in Neuroscience, and Department of Neuroscience, NRB WP13, Georgetown University Medical Center, Washington, DC 20057, USA.
Christy AgbeyInterdisciplinary Program in Neuroscience, and Department of Neuroscience, NRB WP13, Georgetown University Medical Center, Washington, DC 20057, USA.
Italo MocchettiInterdisciplinary Program in Neuroscience, and Department of Neuroscience, NRB WP13, Georgetown University Medical Center, Washington, DC 20057, USA. Electronic address: moccheti@georgetown.edu.
Georgetown University · US

Funding

Role of proBNDF and p75NTR in HIV-mediated Axonal/Dendritic DegenerationR01NS079172 · NINDS · GEORGETOWN UNIVERSITY · PI Italo Mocchetti · 2012 to 2026
$7.0M
Training in Neural Injury &PlasticityT32NS041218 · NINDS · GEORGETOWN UNIVERSITY · PI MARK P BURNS, Kathleen Anne Maguire-Zeiss · 2001 to 2026
$3.5M
Training Program in NeuroHIV (TPNH)T32NS121780 · NINDS · GEORGETOWN UNIVERSITY · PI Marta L. Catalfamo, Italo Mocchetti · 2021 to 2026
$894k
Investigation of Basal Forebrain Degeneration in HIV-Associated Neurocognitive DisorderF31NS124490 · NINDS · GEORGETOWN UNIVERSITY · PI SPEIDELL, ANDREW · 2021 to 2022
$67k
NINDS NIH HHS F31 NS124490NINDS NIH HHS R01 NS079172NINDS NIH HHS T32 NS041218NINDS NIH HHS T32 NS121780
6 · The paper itself

Abstract

Human Immunodeficiency Virus-1 (HIV) infection of the brain induces HIV-associated neurocognitive disorders (HAND). The set of molecular events employed by HIV to drive cognitive impairments in people living with HIV are diverse and remain not completely understood. We have shown that the HIV envelope protein gp120 promotes loss of synapses and decreases performance on cognitive tasks through the p75 neurotrophin receptor (p75

Indexed as

Basal ForebrainHIV-1HIV InfectionsAnimalsCholinergic NeuronsHumansInfantMiceMice, TransgenicReceptor, Nerve Growth FactorReceptor, Nerve Growth FactorConditioned feardiagonal band of BrocaHANDMedial septumNeurodegenerationpeople living with HIVproNGF

Identifiers

PMID38266662
PMCPMC10935610
OpenAlexW4391097508

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.