Evidence map›Paper›PMID 38266122›Full record

ArticleBJS open2024

Textbook outcomes in the liver-first approach for colorectal liver metastases: prospective multicentre analysis.

José M Ramia, Celia Villodre-Tudela, Laia Falgueras-Verdaguer, Natalia Zambudio-Carroll, José T Castell-Gómez, Silvia Carbonell-Morote, Juan L Blas-Laina, Vicente Borrego-Estella, Belinda Sánchez-Pérez, Mario Serradilla-Martín and 1 more

Abstract readMulticenter Study
In one paragraph

Article in BJS open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

José M RamiaDepartment of Surgery, Hospital General Universitario Dr. Balmis, ISABIAL, Universidad Miguel Hernandez, Alicante, Spain.
Celia Villodre-TudelaDepartment of Surgery, Hospital General Universitario Dr. Balmis, ISABIAL, Alicante, Spain.
Laia Falgueras-VerdaguerDepartment of Surgery, Hospital Universitario Dr. Josep Trueta, Girona, Spain.
Natalia Zambudio-CarrollDepartment of Surgery, Hospital Universitario Virgen de las Nieves, Granada, Spain.
José T Castell-GómezDepartment of Surgery, Hospital Universitario La Paz, Madrid, Spain.
Silvia Carbonell-MoroteDepartment of Surgery, Hospital General Universitario Dr. Balmis, ISABIAL, Alicante, Spain.
Juan L Blas-LainaDepartment of Surgery, Hospital Royo Villanova, Zaragoza, Spain.
Vicente Borrego-EstellaDepartment of Surgery, Hospital Universitario Lozano Blesa, Zaragoza, Spain.
Belinda Sánchez-PérezDepartment of Surgery, Hospital Regional Universitario de Málaga, Málaga, Spain.ORCID 0000-0003-1659-5427
Mario Serradilla-MartínInstituto de Investigación Sanitaria Aragón, Department of Surgery, Hospital Universitario Miguel Servet, Zaragoza, Spain.
RENACI Project Collaborative Study Group

Funding

Spanish Association of Surgeons
6 · The paper itself

Abstract

backgroundTextbook outcome is a valuable tool for assessing surgical outcomes. The aim of this study was to analyse textbook-outcome rates in the prospective Spanish National Registry of the Liver-First Approach (RENACI Project) and the factors influencing textbook-outcome achievement. Additionally, a model for assessing a procedure-specific textbook outcome for the liver-first approach was proposed.

methodsA retrospective analysis of a prospective and multicentre database that included consecutive patients with colorectal cancers and synchronous liver metastases who underwent a liver-first approach between June 2019 and August 2020 was performed. Two types of textbook outcome were measured: classic textbook outcome and liver-first-approach-specific textbook outcome (which included negative margins, no perioperative transfusion, no postoperative major surgical complications, no prolonged length of hospital stay, no readmissions, no mortality, and full treatment completion). The primary endpoint was textbook-outcome rate for a liver-first approach at 90 days.

resultsA total of 149 patients were included in the analysis. Classic and liver-first-approach-specific textbook-outcome rates were 71.8 per cent (107 patients) and 46 per cent (69 patients) respectively. Factors significantly associated with liver-first-approach-specific textbook-outcome achievement in the multivariable analysis were the number of metastases (OR 0.82 (95 per cent c.i. 0.73 to 0.92); P = 0.001) and intraoperative blood loss (OR 0.99 (95 per cent c.i. 0.99 to 1.00); P = 0.007). Prolonged length of hospital stay (33 patients, 41 per cent), positive margins (31 patients, 39 per cent), perioperative transfusion (27 patients, 34 per cent), and no full treatment completion (18 patients, 23 per cent) were the items that most frequently prevented liver-first-approach-specific textbook-outcome achievement.

conclusionLiver-first-approach-specific textbook outcome is a promising tool for measuring the quality of care when using the liver-first approach for synchronous colorectal liver metastases.

Indexed as

Colorectal NeoplasmsLiver NeoplasmsHumansPostoperative ComplicationsProspective StudiesRetrospective Studies

Identifiers

PMID38266122
PMCPMC10807998

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.