ArticleScience advances2024
CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice.
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Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
13.2field-weighted citation impact, top 1% of its field
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- CYP46A1 activation by low-dose efavirenz uncovers the link between brain cholesterol metabolism, energetics, and vasculature.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026Article
- Cholesterol metabolism in neurodegenerative diseases: mechanisms and therapeutic advances.Molecular neurodegeneration · 2026Review
- Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Gut microbiota-dependent 24-hydroxycholesterol metabolism contributes to capsaicin-induced amelioration of Alzheimer's disease-like pathology in mice.Nature communications · 2026Article
- Mechanisms, Mediators, and Pharmacological Approaches Targeting Brain Cholesterol Transport in Alzheimer's Disease.Current pharmaceutical design · 2026Review
- Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health.Journal of internal medicine · 2026Review
- Exploring biomarkers of neurodegenerative risk: associations of oxysterols, sex hormones, and reproductive characteristics in older women.Journal of lipid research · 2025Article
- Translational perspectives on women's mental health.The British journal of psychiatry : the journal of mental science · 2025Article
- Brain Cytochrome P450: Navigating Neurological Health and Metabolic Regulation.Journal of xenobiotics · 2025Review
- Commonly prescribed multi-medication therapies exert sex-specific effects on Alzheimer's disease pathology and metabolomic profiles in AppAlzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- GnRH and Cognition.Endocrinology · 2025Review
- The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkinson's disease.PLoS biology · 2025Article
- Mitochondria Metabolism Regulates Glucose-Lipid Homeostasis in Neurodegenerative Diseases.Research (Washington, D.C.) · 2025Review
- Sex, senescence, senolytics, and cognition.Frontiers in aging neuroscience · 2025Review
- Navigating the metabolic maze: anomalies in fatty acid and cholesterol processes in Alzheimer's astrocytes.Alzheimer's research & therapy · 2024Review
- Why women may be more prone to Alzheimer's disease.Aging brain · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 6 institutions in 5 countries.
María Latorre-LealDepartment of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-8434-3822
Patricia Rodriguez-RodriguezDepartment of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-2438-3515
Luca FranchiniDepartment of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
Orestis NikolidakisDepartment of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.ORCID 0009-0006-2685-8736
Makrina DaniilidouDepartment of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
Ljerka DelacDepartment of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-1840-1710
Mukesh K VarshneyDepartment of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-2165-0152
Luis E Arroyo-GarcíaDepartment of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-9206-0179
Francesca EroliDepartment of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
Bengt WinbladDepartment of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-0011-1179
Kaj BlennowInstitute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.ORCID 0000-0002-1890-4193
Henrik ZetterbergInstitute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.ORCID 0000-0003-3930-4354
Miia KivipeltoDepartment of Neurobiology Care Sciences and Society, Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-0992-3875
Manuela PacciariniSwansea University Medical School, SA2 8PP Swansea, UK.
Yuqin WangSwansea University Medical School, SA2 8PP Swansea, UK.ORCID 0000-0002-3063-3066
William J GriffithsSwansea University Medical School, SA2 8PP Swansea, UK.ORCID 0000-0002-4129-6616
Ingemar BjörkhemDepartment of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden.
Anna MattonDepartment of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-7819-0495
Ivan NalvarteDepartment of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-6828-2583
Paula Merino-SerraisDepartment of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-1842-9476
Angel Cedazo-MinguezDepartment of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-4626-4864
Silvia MaioliDepartment of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-9577-0803
Karolinska Institutet · SESwansea University · GBInstituto Cajal · ESKarolinska University Hospital · SESahlgrenska University Hospital · SEUniversity of Science and Technology of China · CN
Funding
Understanding the role of menopause and estrogen receptor activation for Alzheimer's disease riskR01AG065209 · NIA · KAROLINSKA INSTITUTE · PI NALVARTE, IVAN · 2020 to 2023
$1.8MNIA NIH HHS R01 AG065209
Abstract
The brain-specific enzyme CYP46A1 controls cholesterol turnover by converting cholesterol into 24
Indexed as
Alzheimer DiseaseMemory DisordersAgedAnimalsCholesterolCholesterol 24-HydroxylaseCognitionEstrogensFemaleHumansMaleMiceCholesterolCholesterol 24-HydroxylaseEstrogens
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.