Evidence map›Paper›PMID 38266092›Full record

ArticleScience advances2024

Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin.

Wei I Jiang, Henry De Belly, Bingying Wang, Andrew Wong, Minseo Kim, Fiona Oh, Jason DeGeorge, Xinya Huang, Shouhong Guang, Orion D Weiner and 1 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. When Does Stress Build Strength? Linking Stress Physiology to Resilience in the Age of Rapid Environmental Change.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Stress-induced organismal death is genetically regulated by the mTOR-Zeste-Phae1 axis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Review
  11. Review
  12. Suppressing APOE4-induced neural pathologies by targeting the VHL-HIF axis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. Article
  15. Review
  16. Suppressing APOE4-induced mortality and cellular damage by targeting VHL.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Wei I JiangCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-6394-635X
Henry De BellyCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Bingying WangCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Andrew WongCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Minseo KimCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.ORCID 0009-0002-4734-5527
Fiona OhCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Jason DeGeorgeCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.ORCID 0009-0001-9149-5197
Xinya HuangThe USTC RNA Institute, Division of Life Sciences and Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Biomedical Sciences and Health Laboratory of Anhui Province, University of Science and Technology of China, Hefei, Anhui, China.
Shouhong GuangThe USTC RNA Institute, Division of Life Sciences and Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Biomedical Sciences and Health Laboratory of Anhui Province, University of Science and Technology of China, Hefei, Anhui, China.
Orion D WeinerCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-1778-6543
Dengke K MaCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-5619-7485
University of California, San Francisco · USUniversity of Science and Technology of China · CN

Funding

Cellular Decision Making Diversity SupplementR35GM118167 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Orion D Weiner · 2016 to 2026
$10.3M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Genetic pathway and cellular mechanism underlying organismic responses to hypoxia and hypothermiaR35GM139618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Dengke Ma · 2021 to 2026
$2.3M
NIGMS NIH HHS R35 GM118167NIGMS NIH HHS R35 GM139618NIH HHS P40 OD010440
6 · The paper itself

Abstract

Early-life stress experiences can produce lasting impacts on organismal adaptation and fitness. How transient stress elicits memory-like physiological effects is largely unknown. Here, we show that early-life thermal stress strongly up-regulates

Indexed as

Adverse Childhood ExperiencesCaenorhabditis elegans ProteinsResilience, PsychologicalAdultAnimalsCaenorhabditis elegansHistone AcetyltransferasesHumansLongevityTetraspaninsThrombospondin 1Transcription FactorsCaenorhabditis elegans ProteinsCBP-1 protein, C elegansHistone AcetyltransferasesTetraspaninsThrombospondin 1Transcription Factors

Identifiers

PMID38266092
PMCPMC10807809
OpenAlexW4391205558

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.