ArticlePloS one2024
Maternal body mass index and necrotizing enterocolitis: A case-control study.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 4 citations in OpenAlex.
- The impact of pre-pregnancy body mass index and maternal diseases on the offspring outcomes in preterm infants < 32 weeks: five-year retrospective mediation analysis.BMC pregnancy and childbirth · 2026Article
- Maternal High-Fat Diet Worsens Necrotizing Enterocolitis via Effects on Mitochondrial Function in Newborn Mice.Cellular and molecular gastroenterology and hepatology · 2026Article
- Budding baboon blues: the prenatal diet lands a lasting gut punch.American journal of physiology. Gastrointestinal and liver physiology · 2025Article
- Maternal Western diet increases inflammatory markers and decreases barrier function of offspring inAmerican journal of physiology. Gastrointestinal and liver physiology · 2025Article
- A validated NICU database: recounting 50 years of clinical growth, quality improvement and research.Pediatric research · 2025Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
introductionOur aim was to determine if maternal body mass index (BMI) is associated with necrotizing enterocolitis (NEC) in a large urban delivery center.
methodsThis single center retrospective case-control study included 291 infants under gestational age of 33 weeks admitted to the neonatal intensive care unit (NICU) during a 10-year period. Cases of stage 2 and 3 NEC were matched at a ratio of 2 controls (n = 194) to 1 case (n = 97). Maternal BMI was categorized as normal (≤24.9), overweight (25-29.9) and obese (≥30). Chi-square and stepwise logistic regression were used for analysis. A power analysis was performed to determine if sample size was sufficient to detect an association.
resultsStepwise logistic regression demonstrated no association between NEC and maternal obesity. Maternal hypertension, pre-eclampsia, premature rupture of membranes, maternal exposure to antibiotics, placental abruption and gestational diabetes were not associated with NEC. Power analysis showed the sample size was sufficient to detect an association of NEC with maternal BMI in three groups analyzed. In this case-control study, there was an association between NEC and maternal overweight but not obesity at delivery. DISCUSSION: Our results did not show a significant association of NEC with maternal obesity. The percent of overweight and obese mothers prior to pregnancy and at delivery was significantly higher in our population than the national average and may be responsible for the limited ability to reveal any association between maternal obesity and NEC.
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Registered trials
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