Evidence map›Paper›PMID 38265732›Full record

ArticleThe protein journal2024

Interaction of Cecropin A (1-7) Analogs with DNA Analyzed by Multi-spectroscopic Methods.

Libo Yuan, Ke Wang, Yuan Fang, Xiujuan Xu, Yingcun Chen, Dongxin Zhao, Kui Lu

Abstract read
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In one paragraph

Article in The protein journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Libo YuanCollege of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, 450001, People's Republic of China. lbyuan@haut.edu.cn.
Ke WangCollege of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, 450001, People's Republic of China.
Yuan FangPharmacy Department, Zhengzhou People's Hospital, Zhengzhou, 450003, People's Republic of China. fangyuan-25@163.com.
Xiujuan XuCollege of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, 450001, People's Republic of China.
Yingcun ChenCollege of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, 450001, People's Republic of China.
Dongxin ZhaoCollege of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, 450001, People's Republic of China.
Kui LuCollege of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, 450001, People's Republic of China. lukui126@126.com.

Funding

Cultivation Programme for Young Backbone Teachers in Henan University of Technology 21420111National Natural Science Foundation of China 21572046National Natural Science Foundation of China 21708005National Pharmaceutical Care Foundation of China Medicine Education Association CMEAPC2023016Science and Technology Foundation of Henan Province 222102310545
6 · The paper itself

Abstract

Cecropin A (1-7) is a cationic antimicrobial peptide which contain lots of basic amino acids. To understand the effect of basic amino acids on cecropin A (1-7), analogues CA2, CA3 and CA4 which have more arginine or lysine at the N-terminal or C-terminal were designed and synthesized. The interaction of cecropin A (1-7) and its analogs with DNA was studied using ultraviolet-visible spectroscopy, fluorescence spectroscopy and circular dichroism spectroscopy. Multispectral analysis showed that basic amino acids improved the interaction between the analogues and DNA. The interaction between CA4 and DNA is most pronounced. Fluorescence spectrum indicated that Ksv value of CA4 is 1.19 × 10

Indexed as

Circular DichroismDNAEscherichia coliAntimicrobial Cationic PeptidesMicrobial Sensitivity TestsSpectrometry, FluorescenceSpectrophotometry, UltravioletAntimicrobial Cationic Peptidescecropin ADNAAnalogsAntimicrobial peptidesCationic amino acidsCecropin ASpectroscopic methods

Identifiers

PMID38265732

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.