Evidence map›Paper›PMID 38265670›Full record

ArticleClinical oral investigations2024

The tongue microbiome of young patients with chronic kidney disease and their healthy mothers.

Karolin C Hoefer, Lutz T Weber, Anna Greta Barbe, Isabelle Graf, Stefanie Thom, Angela Nowag, Claus J Scholz, Hilmar Wisplinghoff, Michael J Noack, Nathalie Jazmati

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Karolin C HoeferUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Polyclinic for Operative Dentistry and Periodontology, Cologne, Germany. karolin.hoefer@uk-koeln.de.ORCID https://orcid.org/0000-0001-8284-9849
Lutz T WeberChildren´s and Adolescents Hospital, Pediatric Nephrology, University Hospital of Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany.ORCID https://orcid.org/0000-0003-4116-598X
Anna Greta BarbeUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Polyclinic for Operative Dentistry and Periodontology, Cologne, Germany.ORCID https://orcid.org/0000-0003-0169-2582
Isabelle GrafDepartment of Orthodontics, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany.ORCID https://orcid.org/0000-0002-9598-8861
Stefanie ThomWisplinghoff Laboratories, Cologne, Germany.ORCID https://orcid.org/0000-0002-9457-6929
Angela NowagWisplinghoff Laboratories, Cologne, Germany.ORCID https://orcid.org/0009-0008-4034-7988
Claus J ScholzWisplinghoff Laboratories, Cologne, Germany.ORCID https://orcid.org/0000-0002-6406-7859
Hilmar WisplinghoffWisplinghoff Laboratories, Cologne, Germany.
Michael J NoackUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Polyclinic for Operative Dentistry and Periodontology, Cologne, Germany.ORCID https://orcid.org/0000-0001-5303-4616
Nathalie JazmatiWisplinghoff Laboratories, Cologne, Germany.ORCID https://orcid.org/0000-0003-4746-7970
University of Cologne · DELaboratory Dr. Wisplinghoff · DEUniversity Hospital Cologne · DEWitten/Herdecke University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesOral microbiome plays a crucial role in the incidence and development of oral diseases. An altered intestinal microbiome has been reported in adults with chronic kidney disease (CKD). This study aimed to characterize the tongue microbiome of young patients with CKD compared to their healthy mothers to identify the influence of CKD-associated factors on resilient tongue ecosystem. MATERIAL AND

methodsThirty patients with CKD (mean age, 14.2 years; 16 males and 14 females) and generalized gingivitis were included in the study. Swabs of the posterior tongue were collected from the patients and 21 mothers (mean age 40.8 years). Next-generation sequencing of 16S rDNA genes was employed to quantitatively characterize microbial communities.

resultsThe bacterial communities were similar in terms of richness and diversity between patients and mothers (p > 0.05). In patients with CKD, 5 core phyla, 20 core genera, and 12 core species were identified.

conclusionsThe tongue microbiome of the study participants showed no relevant CKD-associated differences compared to their mothers and appears to be a highly preserved niche in the oral cavity. Differences observed in the abundance of individual species in this study could be attributed to the age rather than CKD, even after a mean disease duration of 11 years. CLINICAL RELEVANCE: CKD and its associated metabolic changes appear to have no detectable impact on the resilient tongue microbiome observed in young patients.

Indexed as

GingivitisMicrobiotaRenal Insufficiency, ChronicAdolescentAdultFemaleHumansMaleTongueAdolescentsChildChronic kidney diseaseMicrobiomeMothersTongue

Identifiers

PMID38265670
PMCPMC10808353
OpenAlexW4391170160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.