Evidence map›Paper›PMID 38265549›Full record

ArticleImmunologic research2024

Characteristics of splenic PD-1

Dianhui Chen, Feng Mo, Meiling Liu, Lin Liu, Junmin Xing, Wei Xiao, Yumei Gong, Shanni Tang, Zhengrong Tan, Guikuan Liang and 4 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Immunologic research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. T cell exhaustion in parasitic infections.Frontiers in immunology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Dianhui Chen *Department of Infectious Diseases, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Feng Mo *Department of Infectious Diseases, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Meiling Liu *Clinical Laboratory, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Lin LiuChina Sino-French Hoffmann Institute, Department of basic Medical Science, Guangzhou Medical University, Guangzhou, 511436, China.
Junmin XingChina Sino-French Hoffmann Institute, Department of basic Medical Science, Guangzhou Medical University, Guangzhou, 511436, China.
Wei XiaoChina Sino-French Hoffmann Institute, Department of basic Medical Science, Guangzhou Medical University, Guangzhou, 511436, China.
Yumei GongChina Sino-French Hoffmann Institute, Department of basic Medical Science, Guangzhou Medical University, Guangzhou, 511436, China.
Shanni TangDepartment of Infectious Diseases, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhengrong TanChina Sino-French Hoffmann Institute, Department of basic Medical Science, Guangzhou Medical University, Guangzhou, 511436, China.
Guikuan LiangChina Sino-French Hoffmann Institute, Department of basic Medical Science, Guangzhou Medical University, Guangzhou, 511436, China.
Hongyan XieState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou, China.
Jun HuangChina Sino-French Hoffmann Institute, Department of basic Medical Science, Guangzhou Medical University, Guangzhou, 511436, China. hj165@sina.com.ORCID 0000-0002-6135-1256
Juan ShenKingmed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, Guangdong, 510182, People's Republic of China. shenjuan_lenry@163.com.
Xingfei PanDepartment of Infectious Diseases, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. panxf0125@163.com.
Third Affiliated Hospital of Guangzhou Medical University · CNGuangzhou Medical University · CNState Key Laboratory of Respiratory Disease · CNKingmed Diagnostics · CN

Funding

Guangzhou Science and Technology Project 202002030082Guangzhou Science and Technology Project 202102020092Natural Science Foundation of China 82001747Natural Science Foundation of China 82271798Natural Science Foundation of Guangdong Province 2020A1515010251Natural Science Foundation of Guangdong Province 2021A1515011032Open Foundation Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education 2021kfkt03
6 · The paper itself

Abstract

Although the functions of programmed death-1 (PD-1) on αβ T cells have been extensively reported, a role for PD-1 in regulating γδT cell function is only beginning to emerge. Here, we investigated the phenotypic and functional characteristics of PD-1-expressing γδT cells, and the molecular mechanism was also explored in the Plasmodium yoelii nigeriensis (P. yoelii NSM)-infected mice. Flow cytometry and single-cell RNA sequencing (scRNA-seq) were performed. An inverse agonist of RORα, SR3335, was used to investigate the role of RORα in regulating PD-1

Indexed as

MalariaPlasmodium yoeliiProgrammed Cell Death 1 ReceptorSpleenAnimalsFemaleMiceReceptors, Antigen, T-Cell, gamma-deltaSignal TransductionPdcd1 protein, mouseProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-Cell, gamma-deltaNF-κBPD-1Plasmodium yoelii nigeriensis NSMRORαγδT cells

Identifiers

PMID38265549
PMCPMC11217126
OpenAlexW4391174079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.