Evidence map›Paper›PMID 38265404›Full record

ArticleMicroRNA (Shariqah, United Arab Emirates)2024

Effects of

Arwa R Althaher, Yazun Jarrar, Mahmood Ayad Al-Ibadah, Ruba Balasmeh, Qais Jarrar, Dina Abulebdah

Abstract read
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In one paragraph

Article in MicroRNA (Shariqah, United Arab Emirates), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arwa R AlthaherDepartment of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
Yazun JarrarDepartment of Basic Medical Sciences, Faculty of Medicine, Al-Balqa Applied University, Al-Salt, 19117, Jordan.
Mahmood Ayad Al-IbadahDepartment of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
Ruba BalasmehDepartment of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
Qais JarrarDepartment of Applied Pharmaceutical Sciences and Clinical Pharmacy, Isra University, Amman, Jordan.
Dina AbulebdahDepartment of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlteration in the expression and activity of drug-metabolizing enzymes (DMEs) can alter the pharmacokinetics and hence the response of the drug. Some chemicals found in herbs and fruits affect the expression of DMEs.

aimsThe current investigation aimed to investigate the effect of

methodsThe chemical composition of the ethanoic extract was analyzed using liquid chromatography/ mass spectrometry. Then, 21 BALB/c mice were used for the in vivo experiment. The mice were divided into three groups, each consisting of seven mice. The first group (low-dose group) was treated with 41.6 mg/kg of

resultsThe ethanolic extract of

conclusionIt can be concluded from these findings that consumption of low doses of Calamintha incana upregulated the mRNA expression of mouse cyp3a11 without causing histopathological alterations in the livers. Further studies are needed to determine the influence of

Indexed as

Cytochrome P-450 Enzyme SystemLiverMice, Inbred BALB CPlant ExtractsRNA, MessengerAnimalsEthanolMaleMiceCytochrome P-450 Enzyme SystemEthanolPlant ExtractsRNA, MessengerCalamintha incanacyp3a11cyp450sdrug-metabolizing enzymeslivermouse livers.mRNA expression

Identifiers

PMID38265404

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.