Evidence map›Paper›PMID 38265391›Full record

ArticleCurrent medicinal chemistry2025

Nanoceria Anti-inflammatory and Antimicrobial Nanodrug: Cellular and Molecular Mechanism of Action.

Natalia Cristina Gomes-da-Silva, Luana Barbosa Correa, M MartInez Gonzalez, Alefe Roger Silva Franca, Luciana M R Alencar, Elaine Cruz Rosas, Eduardo Ricci-Junior, Tawanny Kayonara Borges Aguiar, Pedro Filho Noronha Souza, Ralph Santos-Oliveira

Abstract read
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Article in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Natalia Cristina Gomes-da-SilvaLaboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro, 21941906, RJ, Brazil.
Luana Barbosa CorreaLaboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro, 21941906, RJ, Brazil.
M MartInez GonzalezLaboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro, 21941906, RJ, Brazil.
Alefe Roger Silva FrancaBiophysics and Nanosystems Laboratory, Department of Physics, Federal University of Maranhão, São Luis, 65065690, MA, Brazil.
Luciana M R AlencarBiophysics and Nanosystems Laboratory, Department of Physics, Federal University of Maranhão, São Luis, 65065690, MA, Brazil.
Elaine Cruz RosasLaboratory of Applied Pharmacology, Farmanguinhos, Oswaldo Cruz Foundation, Rio de Janeiro, 21041361, Brazil.
Eduardo Ricci-JuniorSchool of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, 21941900, RJ, Brazil.
Tawanny Kayonara Borges AguiarDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, 60451-970, CE, Brazil.
Pedro Filho Noronha SouzaDepartment of Physiology and Pharmacology, Drug Research and Development Center, Federal University of Ceará, Fortaleza, 60430-275, CE, Brazil.
Ralph Santos-OliveiraLaboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro, 21941906, RJ, Brazil.

Funding

Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State (FAPERJ) E-26/200.815/2021, E-26/010.000981/2019, E-26/010.002362/2019, E-26/ 211.269/2021CNPq, Conselho Nacional de Desenvolvimento Científico e Tecnológico 1B: 301069/2018-2, 2: 304774/2021-9Infraestrutura e Pesquisa na UEZO e UERJ E-26//211.207/2021, E-26/202.320/2021
6 · The paper itself

Abstract

introductionNanoceria is a well-known nanomaterial with various properties, including antioxidant, proangiogenic, and therapeutic effects. Despite its potential, there are still aspects that require further exploration, particularly its anti-inflammatory and antimicrobial activities.

methodsThe global demand for novel anti-inflammatory and antimicrobial drugs underscores the significance of understanding nanoceria in both contexts. In this study, we evaluated the effect of nanoceria on macrophage polarization to better understand its anti-inflammatory effects. Additionally, we investigated the mechanism of action of nanoceria against

resultsThe results demonstrated that nanoceria can polarize macrophages toward an anti-inflammatory profile, revealing the cellular mechanisms involved in the anti-inflammatory response. Concerning the antimicrobial effect, it was observed that nanoceria have a more pronounced impact on

conclusionFinally, biochemical analysis revealed transitory alterations, mainly in liver enzymes. The data support the use of nanoceria as a potential anti-inflammatory and antimicrobial drug and elucidate some of the mechanisms involved, shedding light on the properties of this nanodrug.

Indexed as

Antifungal AgentsAnti-Infective AgentsAnti-Inflammatory AgentsCeriumNanoparticlesAnimalsCandidaCandida albicansCryptococcus neoformansHumansMacrophagesMiceMicrobial Sensitivity TestsAntifungal AgentsAnti-Infective AgentsAnti-Inflammatory Agentsceric oxideCeriumAnti-inflammatoryantimicrobial.antimicrobial resistanceantioxidantcandidadrug delivery

Identifiers

PMID38265391

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.