Evidence map›Paper›PMID 38265380›Full record

ReviewCurrent pharmaceutical biotechnology2024

The Astonishing Accomplishment of Biological Drug Delivery using Lipid Nanoparticles: An Ubiquitous Review.

Devesh Kapoor, Shirisha C Chilkapalli, Bhupendra G Prajapati, Paul Rodriques, Ravish Patel, Sudarshan Singh, Sankha Bhattacharya

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pharmaceutical biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Devesh KapoorDepartment of Pharmaceutical Technology, Dr. Dayaram Patel Pharmacy College, Bardoli 394601, Gujarat, India.
Shirisha C ChilkapalliDepartment of Pharmaceutical Technology, Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana-384012, Gujarat, India.
Bhupendra G PrajapatiDepartment of Pharmaceutical Technology, Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana-384012, Gujarat, India.
Paul RodriquesDepartment of Pharmaceutical Technology, Krishna School of Pharmacy and Research, KPGU, Vadodara, Mumbai NH#8, Varnama, Vadodara, Gujarat, India.
Ravish PatelDepartment of Pharmaceutical Technology, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus, Changa 388 421, Anand, Gujarat, India.
Sudarshan SinghDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Sankha BhattacharyaDepartment of Pharmaceutics, School of Pharmacy & Technology Management, SVKM's NMIMS Deemed-to-be University, Shirpur, Maharashtra 425405, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biotech drugs, including proteins, hormones, enzymes, DNA/RNA therapies, and cell-based treatments, are gaining popularity due to their effectiveness. However, effective delivery systems are needed to overcome administration challenges. Lipid nanoparticles (LNPs) have emerged as promising carriers for various therapies. LNPs are biocompatible, less likely to cause adverse reactions, and can stabilize delicate biological drugs, enhancing their stability and solubility. Scalable and cost-effective manufacturing processes make LNPs suitable for largescale production. Despite recent research efforts, challenges in stability, toxicity, and regulatory concerns have limited the commercial availability of LNP-based products. This review explores the applications, administration routes, challenges, and future directions of LNPs in delivering biopharmaceuticals.

Indexed as

LipidsNanoparticlesAnimalsBiological ProductsDrug CarriersDrug Delivery SystemsHumansLiposomesBiological ProductsDrug CarriersLipid NanoparticlesLipidsLiposomesbiologicalsDNA/RNA therapies.Lipid nanoparticlesnucleic acidsprotein-based productsvaccines

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.