Evidence map›Paper›PMID 38265343›Full record

SynthesisBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2024

Influence of the addition of nanohydroxyapatite to scaffolds on proliferation and differentiation of human mesenchymal stem cells: a systematic review of in vitro studies.

E L de Melo, P P A S Cavalcanti, C L Pires, B V A Tostes, J M Miranda, A A Barbosa, S I S da Rocha, N S Deama, S Alves Junior, M E M M Gerbi

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

E L de MeloPrograma de Pós-graduação em Odontologia, Universidade de Pernambuco, Recife, PE, Brasil.ORCID http://orcid.org/0000-0001-5845-1478
P P A S CavalcantiGraduação em Odontologia, Universidade de Pernambuco, Recife, PE, Brasil.ORCID http://orcid.org/0000-0001-8102-1863
C L PiresPrograma de Pós-graduação em Odontologia, Universidade de Pernambuco, Recife, PE, Brasil.ORCID http://orcid.org/0000-0003-3178-9537
B V A TostesPrograma de Pós-graduação em Química, Universidade Federal de Pernambuco, Recife, PE, Brasil.ORCID http://orcid.org/0009-0004-1183-5270
J M MirandaPrograma de Pós-graduação em Odontologia, Universidade de Pernambuco, Recife, PE, Brasil.ORCID http://orcid.org/0000-0003-2882-5103
A A BarbosaUniversidade Federal do Vale do São Francisco, Senhor do Bonfim, BA, Brasil.ORCID http://orcid.org/0000-0003-0266-4604
S I S da RochaPrograma de Pós-graduação em Odontologia, Universidade de Pernambuco, Recife, PE, Brasil.ORCID http://orcid.org/0009-0004-8133-0825
N S DeamaPrograma de Pós-graduação em Odontologia, Universidade de Pernambuco, Recife, PE, Brasil.ORCID http://orcid.org/0000-0002-5327-7084
S Alves JuniorPrograma de Pós-graduação em Química, Universidade Federal de Pernambuco, Recife, PE, Brasil.ORCID http://orcid.org/0000-0002-8092-4224
M E M M GerbiPrograma de Pós-graduação em Odontologia, Universidade de Pernambuco, Recife, PE, Brasil.ORCID http://orcid.org/0000-0001-9174-2541

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the main challenges of tissue engineering in dentistry is to replace bone and dental tissues with strategies or techniques that simulate physiological tissue repair conditions. This systematic review of in vitro studies aimed to evaluate the influence of the addition of nanohydroxyapatite (NHap) to scaffolds on cell proliferation and osteogenic and odontogenic differentiation of human mesenchymal stem cells. In vitro studies on human stem cells that proliferated and differentiated into odontogenic and osteogenic cells in scaffolds containing NHap were included in this study. Searches in PubMed/MEDLINE, Scopus, Web of Science, OpenGrey, ProQuest, and Cochrane Library electronic databases were performed. The total of 333 articles was found across all databases. After reading and analyzing titles and abstracts, 8 articles were selected for full reading and extraction of qualitative data. Results showed that despite the large variability in scaffold composition, NHap-containing scaffolds promoted high rates of cell proliferation, increased alkaline phosphatase (ALP) activity during short culture periods, and induced differentiation, as evidenced by the high expression of genes involved in osteogenesis and odontogenesis. However, further studies with greater standardization regarding NHap concentration, type of scaffolds, and evaluation period are needed to observe possible interference of these criteria in the action of NHap on the proliferation and differentiation of human stem cells.

Indexed as

Data AccuracyMesenchymal Stem CellsPyrenesCell DifferentiationCell ProliferationHumansN-hydroxy-2-aminopyrenePyrenes

Identifiers

PMID38265343
PMCPMC10802233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.