Evidence map›Paper›PMID 38265339›Full record

ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2024

CETP gene polymorphisms and haplotypes are explanatory variables for HDL cholesterol level in sickle cell disease.

N R C Cruz, T N S Valente, F O Ferreira, L R Macedo, A R Belisário, C M da Silva, N S Oliveira, A F F Gomides, C Velloso-Rodrigues

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Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

N R C CruzLaboratório de Biologia Celular e Genética Molecular, Departamento de Nutrição, Universidade Federal de Juiz de Fora - Campus Governador Valadares, Governador Valadares, MG, Brasil.ORCID http://orcid.org/0000-0003-0820-6604
T N S ValenteLaboratório de Biologia Celular e Genética Molecular, Departamento de Ciências Básicas da Vida, Universidade Federal de Juiz de Fora - Campus Governador Valadares, Governador Valadares, MG, Brasil.ORCID http://orcid.org/0000-0002-5708-7325
F O FerreiraDepartamento de Ciências Básicas da Vida, Universidade Federal de Juiz de Fora - Campus Governador Valadares, Governador Valadares, MG, Brasil.ORCID http://orcid.org/0000-0002-5857-2824
L R MacedoDepartamento de Economia, Universidade Federal de Juiz de Fora - Campus Governador Valadares, Governador Valadares, MG, Brasil.ORCID http://orcid.org/0000-0001-6144-7947
A R BelisárioCentro de Tecidos Biológicos, Fundação Hemominas, Lagoa Santa, MG, Brasil.ORCID http://orcid.org/0000-0003-0166-4258
C M da SilvaFaculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, MG, Brasil.ORCID http://orcid.org/0000-0003-3674-4266
N S OliveiraLaboratório de Biologia Celular e Genética Molecular, Departamento de Nutrição, Universidade Federal de Juiz de Fora - Campus Governador Valadares, Governador Valadares, MG, Brasil.ORCID http://orcid.org/0000-0002-7849-4691
A F F GomidesLaboratório de Biologia Celular e Genética Molecular, Departamento de Ciências Básicas da Vida, Universidade Federal de Juiz de Fora - Campus Governador Valadares, Governador Valadares, MG, Brasil.ORCID http://orcid.org/0000-0001-5540-2734
C Velloso-RodriguesLaboratório de Biologia Celular e Genética Molecular, Departamento de Ciências Básicas da Vida, Universidade Federal de Juiz de Fora - Campus Governador Valadares, Governador Valadares, MG, Brasil.ORCID http://orcid.org/0000-0002-4998-1765

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Variations in lipid profile have been observed in sickle cell disease (SCD) and understanding their relationship with disease severity is crucial. This study aimed to investigate the association of polymorphisms of the CETP gene and laboratory markers of disease severity with lipid profile in a pediatric population with SCD. Biochemical and anthropometric analyses and CETP and alpha-thalassemia genotyping were performed. The study included 133 children and adolescents with sickle cell anemia (SCA) or hemoglobin SC disease (SCC), in steady-state. The SCA and no hydroxyurea (no HU) groups had higher values of ApoB, total cholesterol, low-density lipoprotein cholesterol (LDL-C), and non-high-density lipoprotein cholesterol (non-HDL-C) compared to the SCC and HU groups. However, there were no significant differences in ApoA1 and HDL-C levels between the groups based on genotype. Furthermore, the groups with altered levels of ApoA1, HDL-C, and the triglyceride/HDL ratio exhibited lower hemoglobin (Hb) levels and higher white blood cell counts. Hb level was associated to HDL-C levels. Analysis of CETP gene variants showed that the minor alleles of rs3764261 (C>A), rs247616 (C>T), and rs183130 (C>T), as well as the TTA haplotype, are explanatory variables for HDL-C levels. These findings suggested that dyslipidemia in SCD, specifically related to HDL-C levels, may be influenced by individual genetic background. Additionally, further investigation is needed to determine if clinical manifestations are impacted by CETP gene variants.

Indexed as

Anemia, Sickle CellAdolescentAllelesChildCholesterol Ester Transfer ProteinsCholesterol, HDLGenotypeHaplotypesHumansCETP protein, humanCholesterol Ester Transfer ProteinsCholesterol, HDL

Identifiers

PMID38265339
PMCPMC10802225

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.