Evidence map›Paper›PMID 38264997›Full record

ArticleJournal of agricultural and food chemistry2024

Rational Design of a Potential New Nematicide Targeting Chitin Deacetylase.

Maria Galvez-Llompart, Riccardo Zanni, David Vela-Corcía, Álvaro Polonio, Facundo Perez-Gimenez, Jesús Martínez-Cruz, Diego Romero, Dolores Fernández-Ortuño, Alejandro Pérez-García, Jorge Galvez

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of agricultural and food chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Maria Galvez-LlompartDepartment of Preventive Medicine and Public Health, Food Science, Toxicology and Forensic Medicine, Faculty of Pharmacy, University of Valencia, Burjassot, Valencia 46100, Spain.ORCID 0000-0002-0718-4143
Riccardo ZanniMolecular Topology and Drug Design Unit. Department of Physical Chemistry, University of Valencia, Burjassot, Valencia 46100, Spain.ORCID 0000-0002-3388-3730
David Vela-CorcíaDepartment of Microbiology, Faculty of Science, Instituto de Hortofruticultura Subtropical y Mediterránea La Mayora, IHSM-UMA-CSIC, University of Málaga, Málaga 29071, Spain.
Álvaro PolonioDepartment of Microbiology, Faculty of Science, Instituto de Hortofruticultura Subtropical y Mediterránea La Mayora, IHSM-UMA-CSIC, University of Málaga, Málaga 29071, Spain.
Facundo Perez-GimenezMolecular Topology and Drug Design Unit. Department of Physical Chemistry, University of Valencia, Burjassot, Valencia 46100, Spain.
Jesús Martínez-CruzDepartment of Microbiology, Faculty of Science, Instituto de Hortofruticultura Subtropical y Mediterránea La Mayora, IHSM-UMA-CSIC, University of Málaga, Málaga 29071, Spain.
Diego RomeroDepartment of Microbiology, Faculty of Science, Instituto de Hortofruticultura Subtropical y Mediterránea La Mayora, IHSM-UMA-CSIC, University of Málaga, Málaga 29071, Spain.
Dolores Fernández-OrtuñoDepartment of Microbiology, Faculty of Science, Instituto de Hortofruticultura Subtropical y Mediterránea La Mayora, IHSM-UMA-CSIC, University of Málaga, Málaga 29071, Spain.
Alejandro Pérez-GarcíaDepartment of Microbiology, Faculty of Science, Instituto de Hortofruticultura Subtropical y Mediterránea La Mayora, IHSM-UMA-CSIC, University of Málaga, Málaga 29071, Spain.
Jorge GalvezMolecular Topology and Drug Design Unit. Department of Physical Chemistry, University of Valencia, Burjassot, Valencia 46100, Spain.ORCID 0000-0003-0928-8437
Instituto de Hortofruticultura Subtropical y Mediterránea "La Mayora" · ESUniversitat de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a previously published study, the authors devised a molecular topology QSAR (quantitative structure-activity relationship) approach to detect novel fungicides acting as inhibitors of chitin deacetylase (CDA). Several of the chosen compounds exhibited noteworthy activity. Due to the close relationship between chitin-related proteins present in fungi and other chitin-containing plant-parasitic species, the authors decided to test these molecules against nematodes, based on their negative impact on agriculture. From an overall of 20 fungal CDA inhibitors, six showed to be active against

Indexed as

AmidohydrolasesCaenorhabditis elegansNematodaAnimalsAntinematodal AgentsChitinMolecular Docking SimulationAmidohydrolasesAntinematodal AgentsChitinchitin deacetylaseCaenorhabditis eleganschitin deacetylasemolecular topologynematicideQSAR

Identifiers

PMID38264997
PMCPMC10853968
OpenAlexW4391157150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.