Evidence map›Paper›PMID 38264934›Full record

ArticleJournal of cell science2024

Role of BicDR in bristle shaft construction and support of BicD functions.

Aleksandra Jejina, Yeniffer Ayala, Dirk Beuchle, Thomas Höhener, Ruth E Dörig, Paula Vazquez-Pianzola, Greco Hernández, Beat Suter

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In one paragraph

Article in Journal of cell science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Aleksandra JejinaInstitute of Cell Biology, University of Bern, CH-3012 Bern, Switzerland.
Yeniffer AyalaLaboratory of Translation and Cancer, Unit of Biomedical Research on Cancer, Instituto Nacional de Cancerologıá (INCan), 14080 Tlalpan, Mexico City, Mexico.
Dirk BeuchleInstitute of Cell Biology, University of Bern, CH-3012 Bern, Switzerland.
Thomas HöhenerInstitute of Cell Biology, University of Bern, CH-3012 Bern, Switzerland.
Ruth E DörigInstitute of Cell Biology, University of Bern, CH-3012 Bern, Switzerland.
Paula Vazquez-PianzolaInstitute of Cell Biology, University of Bern, CH-3012 Bern, Switzerland.
Greco HernándezLaboratory of Translation and Cancer, Unit of Biomedical Research on Cancer, Instituto Nacional de Cancerologıá (INCan), 14080 Tlalpan, Mexico City, Mexico.
Beat SuterInstitute of Cell Biology, University of Bern, CH-3012 Bern, Switzerland.ORCID 0000-0002-0510-746X

Funding

Resource Project CoreU41HG000739 · NHGRI · HARVARD UNIVERSITY · PI PERRIMON, NORBERT · 2014 to 2022
$32.3M
NHGRI NIH HHS U41 HG000739Swiss National Science Foundation 31003A_173188
6 · The paper itself

Abstract

Cell polarization requires asymmetric localization of numerous mRNAs, proteins and organelles. The movement of cargo towards the minus end of microtubules mostly depends on cytoplasmic dynein motors. In the dynein-dynactin-Bicaudal-D transport machinery, Bicaudal-D (BicD) links the cargo to the motor. Here, we focus on the role of Drosophila BicD-related (BicDR, CG32137) in the development of the long bristles. Together with BicD, it contributes to the organization and stability of the actin cytoskeleton in the not-yet-chitinized bristle shaft. BicD and BicDR also support the stable expression and distribution of Rab6 and Spn-F in the bristle shaft, including the distal tip localization of Spn-F, pointing to the role of microtubule-dependent vesicle trafficking for bristle construction. BicDR supports the function of BicD, and we discuss the hypothesis whereby BicDR might transport cargo more locally, with BicD transporting cargo over long distances, such as to the distal tip. We also identified embryonic proteins that interact with BicDR and appear to be BicDR cargo. For one of them, EF1γ (also known as eEF1γ), we show that the encoding gene EF1γ interacts with BicD and BicDR in the construction of the bristles.

Indexed as

Drosophila ProteinsAnimalsDrosophilaDynactin ComplexDyneinsMicrotubule-Associated ProteinsMicrotubulesBicD protein, DrosophilaDrosophila ProteinsDynactin ComplexDyneinsMicrotubule-Associated ProteinsSpn-F protein, DrosophilaBicaudal-DBicDBicD-relatedBristle formationDrosophilaMicrotubule vesicle transportRab6Spn-F

Identifiers

PMID38264934
PMCPMC10917063

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.