Evidence map›Paper›PMID 38264929›Full record

ArticleHistology and histopathology2024

Transcription factor YY1 accelerates hepatic fibrosis development by activating NLRP3 inflammasome-mediated pyroptosis.

Xiao Fu, Ping Xiao, Xin Luo, Ninghong Guo

Abstract read
PubMed Publisher
In one paragraph

Article in Histology and histopathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiao FuGeneral Medicine Department, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, PR China.
Ping XiaoGeneral Medicine Department, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, PR China.
Xin LuoGeneral Medicine Department, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, PR China.
Ninghong GuoClinical Trial Center, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, PR China. guoninghong1122@163.com.

Funding

Key R&D projects of the Jiangxi Provincial Department of Science and Technology 20202BBGL73031
6 · The paper itself

Abstract

Hepatic fibrosis is the basis of multiple liver diseases and may eventually develop into hepatocellular carcinoma. Hepatic stellate cell (HSC) activation is a driving factor of hepatic fibrogenesis. In the liver microenvironment, liver cells and others play a crucial role in HSC activation. The liver tissues of CCl4-induced rats show excessive fibrosis, inflammation, and cell apoptosis. Yin Yang 1 (YY1) was highly expressed in hepatic fibrosis rats and TGF-β1-treated liver cells. In animal experiments, YY1 knockdown effectively attenuated CCl

Indexed as

Hepatic Stellate CellsInflammasomesLiver CirrhosisNLR Family, Pyrin Domain-Containing 3 ProteinPyroptosisYY1 Transcription FactorAnimalsInterleukin-1betaLiverMaleRatsRats, Sprague-DawleyTransforming Growth Factor beta1InflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratTransforming Growth Factor beta1Yy1 protein, ratYY1 Transcription Factor

Identifiers

PMID38264929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.