Evidence map›Paper›PMID 38264714›Full record

ArticlePatterns (New York, N.Y.)2024

LATTE: Label-efficient incident phenotyping from longitudinal electronic health records.

Jun Wen, Jue Hou, Clara-Lea Bonzel, Yihan Zhao, Victor M Castro, Vivian S Gainer, Dana Weisenfeld, Tianrun Cai, Yuk-Lam Ho, Vidul A Panickan and 7 more

Abstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jun WenHarvard Medical School, Boston, MA, USA.
Jue HouUniversity of Minnesota, Minneapolis, MN, USA.
Clara-Lea BonzelHarvard Medical School, Boston, MA, USA.
Yihan ZhaoHarvard University, Cambridge, MA, USA.
Victor M CastroMass General Brigham, Boston, MA, USA.
Vivian S GainerMass General Brigham, Boston, MA, USA.
Dana WeisenfeldBrigham and Women's Hospital, Boston, MA, USA.
Tianrun CaiVA Boston Healthcare System, Boston, MA, USA.
Yuk-Lam HoVA Boston Healthcare System, Boston, MA, USA.
Vidul A PanickanHarvard Medical School, Boston, MA, USA.
Lauren CostaVA Boston Healthcare System, Boston, MA, USA.
Chuan HongDuke University, Durham, NC, USA.
J Michael GazianoHarvard Medical School, Boston, MA, USA.
Katherine P LiaoHarvard Medical School, Boston, MA, USA.
Junwei LuVA Boston Healthcare System, Boston, MA, USA.
Kelly ChoHarvard Medical School, Boston, MA, USA.
Tianxi CaiHarvard Medical School, Boston, MA, USA.

Funding

Bridging clinical trial and real-world data via machine learning to advance rheumatoid arthritis treatment strategiesR01AR080193 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI CAI, TIANXI, LIAO, KATHERINE PHOENIX · 2022 to 2025
$2.7M
Generating Reproducible Real-World Evidence with Multi-Source Data to Capture Unstructured Clinical Endpoints for Chronic DiseasesU01FD007929 · FDA · HARVARD MEDICAL SCHOOL · PI BOURGEOIS, FLORENCE, CAI, TIANXI · 2023 to 2024
$2.2M
Semi-supervised Approaches to Denoising Electronic Health Records Data for Risk PredictionR01LM013614 · NLM · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI CAI, TIANXI, GUO, ZIJIAN · 2021 to 2024
$1.4M
FDA HHS U01 FD007929NIAMS NIH HHS R01 AR080193NLM NIH HHS R01 LM013614
6 · The paper itself

Abstract

Electronic health record (EHR) data are increasingly used to support real-world evidence studies but are limited by the lack of precise timings of clinical events. Here, we propose a label-efficient incident phenotyping (LATTE) algorithm to accurately annotate the timing of clinical events from longitudinal EHR data. By leveraging the pre-trained semantic embeddings, LATTE selects predictive features and compresses their information into longitudinal visit embeddings through visit attention learning. LATTE models the sequential dependency between the target event and visit embeddings to derive the timings. To improve label efficiency, LATTE constructs longitudinal silver-standard labels from unlabeled patients to perform semi-supervised training. LATTE is evaluated on the onset of type 2 diabetes, heart failure, and relapses of multiple sclerosis. LATTE consistently achieves substantial improvements over benchmark methods while providing high prediction interpretability. The event timings are shown to help discover risk factors of heart failure among patients with rheumatoid arthritis.

Identifiers

PMID38264714
PMCPMC10801250

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.