Evidence map›Paper›PMID 38264664›Full record

ArticleFrontiers in immunology2023

Limitations and potential of immunotherapy in ovarian cancer.

Sandeep Kumar, Sayanti Acharya, Mahalakshmi Karthikeyan, Priyobrata Biswas, Sudha Kumari

Abstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sandeep Kumar *Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Sayanti Acharya *Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Mahalakshmi KarthikeyanDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Priyobrata BiswasDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Sudha KumariDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer (OC) is the third most common gynecological cancer and alone has an emergence rate of approximately 308,069 cases worldwide (2020) with dire survival rates. To put it into perspective, the mortality rate of OC is three times higher than that of breast cancer and it is predicted to only increase significantly by 2040. The primary reasons for such a high rate are that the physical symptoms of OC are detectable only during the advanced phase of the disease when resistance to chemotherapies is high and around 80% of the patients that do indeed respond to chemotherapy initially, show a poor prognosis subsequently. This highlights a pressing need to develop new and effective therapies to tackle advanced OC to improve prognosis and patient survival. A major advance in this direction is the emergence of combination immunotherapeutic methods to boost CD8

Indexed as

Breast NeoplasmsOvarian NeoplasmsCarcinoma, Ovarian EpithelialCD8-Positive T-LymphocytesFemaleHumansImmunotherapycheckpoint inhibitorsimmunosuppressionimmunotherapyovarian cancerT cells

Identifiers

PMID38264664
PMCPMC10803592

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.