Evidence map›Paper›PMID 38264653›Full record

ReviewFrontiers in immunology2023

Recent advances in understanding the human host immune response in tuberculous meningitis.

James R Barnacle, Angharad G Davis, Robert J Wilkinson

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Towards host-directed therapy: The role of matrix metalloproteinases in the immunopathogenesis of tuberculosis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Journal of bacteriology · 2025
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

James R BarnacleThe Francis Crick Institute, London, United Kingdom.
Angharad G DavisThe Francis Crick Institute, London, United Kingdom.
Robert J WilkinsonThe Francis Crick Institute, London, United Kingdom.
Imperial College London · GBWellcome Centre for Infectious Diseases Research in Africa · ZA

Funding

Translational approaches to improve understanding and outcome in Tuberculous meningitisR01AI145436 · NIAID · HACKENSACK UNIVERSITY MEDICAL CENTER · PI GENGENBACHER, MARTIN ALFONS, LAI, RACHEL PEI JEN · 2020 to 2024
$3.6M
Medical Research CouncilNIAID NIH HHS R01 AI145436Wellcome Trust 203135/Z/16/ZWellcome Trust CC2112
6 · The paper itself

Abstract

Tuberculous meningitis (TBM), the most severe form of tuberculosis, causes death in approximately 25% cases despite antibiotic therapy, and half of survivors are left with neurological disability. Mortality and morbidity are contributed to by a dysregulated immune response, and adjunctive host-directed therapies are required to modulate this response and improve outcomes. Developing such therapies relies on improved understanding of the host immune response to TBM. The historical challenges in TBM research of limited

Indexed as

MicroRNAsMycobacterium tuberculosisTuberculosis, MeningealAdultB-LymphocytesCentral Nervous SystemChildHumansMicroRNAsextrapulmonary tuberculosis (EPTB)host-directed therapyimmune responseimmunityMycobacterium tuberculosistuberculosistuberculous meningitis (TBM)

Identifiers

PMID38264653
PMCPMC10803428
OpenAlexW4390757818

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.