Evidence map›Paper›PMID 38264209›Full record

ArticleFrontiers in genetics2023

Placental cytochrome P450 methylomes in infants exposed to prenatal opioids: exploring the effects of neonatal opioid withdrawal syndrome on health horizons.

Uppala Radhakrishna, Senthilkumar Sadhasivam, Rupa Radhakrishnan, Ariadna Forray, Srinivas B Muvvala, Raghu P Metpally, Saumya Patel, Rakesh M Rawal, Sangeetha Vishweswaraiah, Ray O Bahado-Singh and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Uppala RadhakrishnaDepartment of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
Senthilkumar SadhasivamDepartment of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
Rupa RadhakrishnanDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States.
Ariadna ForrayDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, United States.
Srinivas B MuvvalaDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, United States.
Raghu P MetpallyDepartment of Molecular and Functional Genomics, Geisinger, Danville, PA, United States.
Saumya PatelDepartment of Botany, Bioinformatics and Climate Change Impacts Management, School of Science, Gujarat University, Ahmedabad, India.
Rakesh M RawalDepartment of Life Sciences, School of Sciences, Gujarat University, Ahmedabad, India.
Sangeetha VishweswaraiahDepartment of Obstetrics and Gynecology, Corewell Health William Beaumont University Hospital, Royal Oak, MI, United States.
Ray O Bahado-SinghDepartment of Obstetrics and Gynecology, Corewell Health William Beaumont University Hospital, Royal Oak, MI, United States.
Swapan K NathArthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.

Funding

Perioperative Precision Medicine: Translating Science to Clinical Practice to Improve Safety and Efficacy of Opioids in Neonates, Children and Nursing MothersU01TR003719 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Senthilkumar Sadhasivam · 2022 to 2026
$4.4M
Multimodal Fetal and Placental Imaging and Biomarkers of Clinical Outcomes in Opioid Use DisorderR01DA059321 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Rupa Radhakrishnan, Senthilkumar Sadhasivam · 2023 to 2026
$4.2M
Effects of Opioid Use Disorder in Pregnancy on Long-Term Maternal and Child OutcomesR01HD096800 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SADHASIVAM, SENTHILKUMAR · 2018 to 2022
$3.1M
Development and Commercialization of a pupillometer to predict postoperative opioid-induced respiratory depression in childrenR44DA055407 · NIDA · NEUROPTICS, INC. · PI OLIVER, JEFFREY WADE, PRIVITERA, CLAUDIO · 2022 to 2024
$2.7M
Reduction of opioid requirement associated with Auriculo-nerve stimulation following open surgeryR01DA054513 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHELLY, JACQUES E., SADHASIVAM, SENTHILKUMAR · 2022 to 2025
$2.1M
Improving Analgesic Effectiveness and Safety with Proactive Precision Pain Management in Thoracic Surgical Patients with Lung LesionsR43HL167661 · NHLBI · OPALGENIX, INC. · PI PLUMP, STEVEN R., SADHASIVAM, SENTHILKUMAR · 2023 to 2023
$644k
Avoiding Adverse Opioid Outcomes with Proactive Precision CareR41DA053877 · NIDA · OPALGENIX, INC. · PI PLUMP, STEVEN R., SADHASIVAM, SENTHILKUMAR · 2021 to 2022
$374k
Reducing Opioid Use and Adverse Effects through Proactive Precision Pain Management Following Spine SurgeryR44DA056280 · NIDA · OPALGENIX, INC. · PI PLUMP, STEVEN R., SADHASIVAM, SENTHILKUMAR · 2022 to 2022
$327k
Predicting and Preventing Adverse Maternal and Child Outcomes of Opioid Use Disorder in PregnancyR43DA058430 · NIDA · OPALGENIX, INC. · PI PLUMP, STEVEN R., SADHASIVAM, SENTHILKUMAR · 2023 to 2023
$325k
Neuroimaging in Pregnancy to Assess Effects of Opioid Use DisorderR03DA056797 · NIDA · INDIANA UNIVERSITY INDIANAPOLIS · PI RADHAKRISHNAN, RUPA · 2023 to 2023
$238k
NCATS NIH HHS U01 TR003719NHLBI NIH HHS R43 HL167661NICHD NIH HHS R01 HD096800NIDA NIH HHS R01 DA054513NIDA NIH HHS R01 DA059321NIDA NIH HHS R03 DA056797NIDA NIH HHS R41 DA053877NIDA NIH HHS R43 DA058430NIDA NIH HHS R44 DA055407NIDA NIH HHS R44 DA056280
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

biomarkerCYP1A2CYP1B1CYP24A1CYP4V2cytochromesneonatal opioid withdrawal syndrome CYP19A1opioid use

Identifiers

PMID38264209
PMCPMC10805101

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.