Evidence map›Paper›PMID 38263930›Full record

ArticleEuropean journal of ophthalmology2024

Transcriptome Analysis of Choroidal Endothelium Links Androgen Receptor Role to Central Serous Chorioretinopathy.

Sandrine H Künzel, Dominika Pohlmann, Lynn Zur Bonsen, Matteus Krappitz, Oliver Zeitz, Antonia M Joussen, Alexandre Dubrac, Steffen E Künzel

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In one paragraph

Article in European journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sandrine H KünzelDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
Dominika PohlmannDepartment of Ophthalmology, Charité University Hospital Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-9866-0431
Lynn Zur BonsenDepartment of Ophthalmology, Charité University Hospital Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Matteus KrappitzDepartment of Nephrology and Medical Intensive Care, Charité University Hospital Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Oliver ZeitzDepartment of Ophthalmology, Charité University Hospital Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Antonia M JoussenDepartment of Ophthalmology, Charité University Hospital Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Alexandre DubracDépartement de Pathologie et Biologie Cellulaire, Université de Montréal, Montréal, Quebec, Canada.
Steffen E KünzelDepartment of Ophthalmology, Charité University Hospital Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCentral Serous Chorioretinopathy (CSCR) manifests as fluid accumulation between the neurosensory retina and the retinal pigment epithelium (RPE). Elevated levels of steroid hormones have been implicated in CSCR pathogenesis. This investigation aims to delineate the gene expression patterns of CSCR-associated risk and steroid receptors across human choroidal cell types and RPE cells to discern potential underlying mechanisms.

methodsThis study utilized a comprehensive query of transcriptomic data derived from non-pathological human choroid and RPE cells.

findingsCSCR-associated genes such as

interpretationThese results highlight the proclivity of CSCR to manifest primarily within the choroidal vasculature rather than the RPE, suggesting its categorization as a vascular eye disorder. This study accentuates the pivotal role of androgenic steroids, in addition to glucocorticoids. The observed linkage to TGF-β-mediated endMT provides a potential mechanistic insight into the disease's etiology.

Indexed as

Central Serous ChorioretinopathyChoroidGene Expression ProfilingReceptors, AndrogenRetinal Pigment EpitheliumEndothelium, VascularGene Expression RegulationHumansTranscriptomeTransforming Growth Factor betaAR protein, humanReceptors, AndrogenTransforming Growth Factor betaandrogen receptorCentral serous chorioretinopathychoroidal endotheliumendothelial-Mesenchymal transition (endMT)TGF-βtranscriptome analysis

Identifiers

PMID38263930
PMCPMC11408951

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.