Evidence map›Paper›PMID 38263895›Full record

ReviewCancer science2024

RNA methylation in inflammatory bowel disease.

Yuki Ozato, Tomoaki Hara, Sikun Meng, Hiromichi Sato, Shotaro Tatekawa, Mamoru Uemura, Takeshi Yabumoto, Shizuka Uchida, Kazuhiko Ogawa, Yuichiro Doki and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Cancer science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Yuki OzatoDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Japan.
Tomoaki HaraDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Japan.
Sikun MengDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Japan.
Hiromichi SatoDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Japan.
Shotaro TatekawaDepartment of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Japan.
Mamoru UemuraDepartment of Gastrointestinal Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Takeshi YabumotoKinshu-kai Medical Corporation, Osaka, Japan.
Shizuka UchidaDepartment of Clinical Medicine, Center for RNA Medicine, Aalborg University, Copenhagen SV, Denmark.
Kazuhiko OgawaDepartment of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Japan.
Yuichiro DokiDepartment of Gastrointestinal Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Hidetoshi EguchiDepartment of Gastrointestinal Surgery, Osaka University Graduate School of Medicine, Suita, Japan.ORCID https://orcid.org/0000-0002-2318-1129
Hideshi IshiiDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Japan.ORCID https://orcid.org/0000-0002-0632-6517
Osaka Gakuin University · JPThe University of Osaka · JPAalborg University · DKKishokai Medical Corporation · JP

Funding

Ministry of Education, Culture, Sports, Science and Technology 18KK0251 19K22658 20H00541 21K19526Ministry of Education, Culture, Sports, Science and Technology 22H03146 22K19559 23K19505 16H06279 (PAGS)Ministry of Education, Culture, Sports, Science and Technology grant nos. 17cm0106414h0002 JP21lm0203007Mitsubishi Foundation 2021-48
6 · The paper itself

Abstract

RNA modifications, including the renowned m6A, have recently garnered significant attention. This chemical alteration, present in mRNA, exerts a profound influence on protein expression levels by affecting splicing, nuclear export, stability, translation, and other critical processes. Although the role of RNA methylation in the pathogenesis and progression of IBD and colorectal cancer has been reported, many aspects remain unresolved. In this comprehensive review, we present recent studies on RNA methylation in IBD and colorectal cancer, with a particular focus on m6A and its regulators. We highlight the pivotal role of m6A in the pathogenesis of IBD and colorectal cancer and explore the potential applications of m6A modifications in the diagnosis and treatment of these diseases.

Indexed as

Colorectal NeoplasmsInflammatory Bowel DiseasesHumansRNARNA, MessengerRNA MethylationRNA SplicingRNARNA, Messengercolorectal cancerinflammatory bowel diseasem6AmethylationRNA

Identifiers

PMID38263895
PMCPMC10920996
OpenAlexW4391173313

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.