Evidence map›Paper›PMID 38263802›Full record

ArticleNeurogastroenterology and motility2024

Heterologous expression of the human wild-type and variant Na

Maryam M Kapur, Marwa Soliman, Emily N Blanke, Paul B Herold, Piotr K Janicki, Kent E Vrana, Matthew D Coates, Victor Ruiz-Velasco

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurogastroenterology and motility, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Targeting NaInternational journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Maryam M KapurDepartment of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Marwa SolimanDepartment of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Emily N BlankeDepartment of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Paul B HeroldDepartment of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Piotr K JanickiDepartment of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Kent E VranaDepartment of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Matthew D CoatesDepartment of Gastroenterology and Hepatology, Penn State College of Medicine, Hershey, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-8976-5015
Victor Ruiz-VelascoDepartment of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Penn State Milton S. Hershey Medical Center · US

Funding

The Role of the Voltage-Gated Sodium Channel, NaV1.8, in Silent Inflammatory Bowel DiseaseR01DK122364 · NIDDK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI COATES, MATTHEW D · 2020 to 2023
$1.5M
NIDDK NIH HHS R01 DK122364NIH HHS
6 · The paper itself

Abstract

backgroundSilent inflammatory bowel disease (IBD) is a condition in which individuals with the active disease experience minor to no pain. Voltage-gated Na

methodsEndogenous Na KEY

resultsThe results indicate that 1073A and 1073V Na CONCLUSIONS AND INFERENCES: These findings differ from previous observations in other expression models and underscore the challenges with heterologous expression systems. Therefore, the use of human sensory neurons derived from induced pluripotent stem cells may help address these inconsistencies and better determine the effect of the polymorphism present in IBD patients.

Indexed as

Inflammatory Bowel DiseasesSensory Receptor CellsAnimalsHumansNAV1.8 Voltage-Gated Sodium ChannelPainRatsNAV1.8 Voltage-Gated Sodium ChannelSCN10A protein, humanNaV currentsScn10a polymorphismsilent IBDwhole-cell patch-clamp

Identifiers

PMID38263802
PMCPMC10922522
OpenAlexW4391171417

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.