Evidence map›Paper›PMID 38263608›Full record

ArticleMolecular ecology2025

Evolution of gene expression across brain regions in behaviourally divergent deer mice.

Andreas F Kautt, Jenny Chen, Caitlin L Lewarch, Caroline Hu, Kyle Turner, Jean-Marc Lassance, Felix Baier, Nicole L Bedford, Andres Bendesky, Hopi E Hoekstra

Abstract read
In one paragraph

Article in Molecular ecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Molecular Basis of Behavioral Diversity in a Sibling Species Trio.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andreas F KauttDepartment of Organismic & Evolutionary Biology, Department of Molecular & Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.ORCID 0000-0001-7792-0735
Jenny ChenDepartment of Organismic & Evolutionary Biology, Department of Molecular & Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.
Caitlin L LewarchDepartment of Organismic & Evolutionary Biology, Department of Molecular & Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.
Caroline HuDepartment of Organismic & Evolutionary Biology, Department of Molecular & Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.
Kyle TurnerDepartment of Organismic & Evolutionary Biology, Department of Molecular & Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.
Jean-Marc LassanceDepartment of Organismic & Evolutionary Biology, Department of Molecular & Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.
Felix BaierDepartment of Organismic & Evolutionary Biology, Department of Molecular & Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.
Nicole L BedfordDepartment of Organismic & Evolutionary Biology, Department of Molecular & Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.
Andres BendeskyDepartment of Organismic & Evolutionary Biology, Department of Molecular & Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.ORCID 0000-0002-4220-3653
Hopi E HoekstraDepartment of Organismic & Evolutionary Biology, Department of Molecular & Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.

Funding

The Genetics and Neurobiology of Parental Care in Wild MiceR00HD084732 · NICHD · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI BENDESKY, ANDRES · 2017 to 2019
$741k
The genetics and neurobiology of parental care in wild miceK99HD084732 · NICHD · HARVARD UNIVERSITY · PI BENDESKY, ANDRES · 2015 to 2016
$251k
The genetic control of neuronal number and behaviorK99GM146243 · NIGMS · HARVARD UNIVERSITY · PI CHEN, JENNIFER · 2022 to 2023
$216k
NICHD NIH HHS K99 HD084732NICHD NIH HHS R00 HD084732NIGMS NIH HHS K99 GM146243
6 · The paper itself

Abstract

The evolution of innate behaviours is ultimately due to genetic variation likely acting in the nervous system. Gene regulation may be particularly important because it can evolve in a modular brain-region specific fashion through the concerted action of cis- and trans-regulatory changes. Here, to investigate transcriptional variation and its regulatory basis across the brain, we perform RNA sequencing (RNA-Seq) on ten brain subregions in two sister species of deer mice (Peromyscus maniculatus and P. polionotus)-which differ in a range of innate behaviours, including their social system-and their F

Indexed as

Behavior, AnimalBrainEvolution, MolecularGene ExpressionPeromyscusAnimalsBiological EvolutionFemaleGene Expression RegulationGenetic VariationMaleSequence Analysis, RNAbrain evolutiondeer mousegene expressiongene regulation

Identifiers

PMID38263608
PMCPMC12288816

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.