ArticleClinical and experimental reproductive medicine2024
Prevalence and confounders of chronic endometritis diagnosed using CD138 in patients with recurrent implantation failure.
Article in Clinical and experimental reproductive medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Diagnostic Accuracy of MUM1 (IRF4) Immunohistochemistry in Chronic Endometritis: A Systematic Review and Bayesian Meta-Analysis.Diagnostics (Basel, Switzerland) · 2026Review
- Early screening and post-treatment chronic endometritis in subsequent frozen embryo transfer cycles among women with first implantation failure: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Impaired SREBP1-mediated regulation of lipid metabolism promotes inflammation in chronic endometritis.Frontiers in immunology · 2025Article
- Correlation of hysteroscopic findings of chronic endometritis with CD138 immunohistochemistry and their correlation with pregnancy outcomes.Journal of assisted reproduction and genetics · 2024Observational
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Authors and funding
7 authors.
Funding
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Abstract
objectiveThis retrospective study aimed to investigate the prevalence of chronic endometritis, diagnosed using CD138 immunohistochemistry, among infertile women and to assess the association between chronic endometritis and recurrent implantation failure (RIF).
methodsIn total, 266 patients who underwent hysteroscopy due to infertility between 2019 and 2020 were included in the analysis. Of these, 136 patients with RIF and 130 non-RIF patients were included in the study. CD138 immunohistochemistry test results, blood biomarkers (including natural killer cells, white blood cells, and the lymphocyte-to-neutrophil ratio), and data on pregnancy outcomes were obtained. If the CD138 test yielded a positive result, the patients received antibiotic treatment.
resultsThe overall proportion of CD138-positive patients was 32.7% (87/266). The CD138 positivity rate was not related to the number of cycles with implantation failure. In the RIF patient group, no significant associations were found between CD138 positivity and peripheral blood markers. The clinical pregnancy rates were similar between infertile women treated with antibiotics for chronic endometritis and those without chronic endometritis.
conclusionTo improve the pregnancy rate in infertile patients, it may be helpful to combine CD138 testing with other laboratory tests and administer antibiotic treatment if the result is positive.
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