ArticleColorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland2024
Tumour deposits are independently associated with recurrence in colon cancer.
Article in Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 8 citations in OpenAlex.
- Prognostic importance of tumour deposits with and without concurrent lymph node metastases in patients with stage III colon cancer.BJS open · 2026Article
- Preoperative identification of tumor deposits in rectal cancer using a transformer-based multimodal fusion model: a multicenter retrospective study.BMC medical imaging · 2026Article
- Article
- Machine learning-based integration of tumor deposit molecular signatures improves prognostic stratification in colon adenocarcinoma.International journal of colorectal disease · 2026Article
- Complete Mesocolic Excision for Colon Cancer: Insight into Potential Mechanisms of Oncologic Benefit.Cancers · 2025Review
- Mesentery morphological features on computed tomography for preoperative prediction of tumor invasion and lymph node metastasis in colon cancer.World journal of clinical oncology · 2025Article
- Spectral computed tomography parameters of primary tumors and lymph nodes for predicting tumor deposits in colorectal cancer.World journal of radiology · 2025Article
- Tumor Deposits in Non-Metastatic Colorectal Cancer as a Risk Factor of Peritoneal Metastasis.International journal of medical sciences · 2025Article
- Prognostic Value of Tumor Deposits in Patients with Colorectal Cancer.Journal of Cancer · 2024Article
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15 authors at 1 institution in 1 country.
Funding
Abstract
aimTumour deposits are focal aggregates of cancer cells in pericolic fat and mesentery, distinct from vessels, nerves and lymphatics. Their presence upstages lymph node negative patients but is ignored in lymph node positive patients. We investigated the clinicopathological factors associated with tumour deposits and their impact on recurrence in lymph node positive and negative patients.
methodClinicopathological variables were collected from the medical records of patients with Stage I-III colon cancer who underwent resection in 2017-2019. Pathology was reviewed by a gastrointestinal pathologist. Patients with rectal cancer, metastasis, and concurrent malignancy were excluded.
resultsTumour deposits were noted in 69 (9%) of 770 patients. They were associated with the presence of lymph node metastasis, advanced T category, poorly differentiated tumours, microsatellite stable subtype and lymphovascular and perineural invasion (p < 0.05). The presence of tumour deposits (hazard ratio 2.48, 95% CI 1.49-4.10) and of lymph node metastasis (hazard ratio 3.04, 95% CI 1.72-5.37) were independently associated with decreased time to recurrence. There was a weak correlation (0.27) between the number of tumour deposits and the number of positive lymph nodes.
conclusionTumour deposits are associated with more advanced disease and high-risk pathological features. The presence of tumour deposits and lymph node metastasis were found to be independent risk factors for decreased time to recurrence. A patient with both lymph node metastasis and tumour deposits is more than twice as likely to have recurrence compared with a patient with only lymph node metastasis. Tumour deposits independently predict recurrence and should not be ignored in lymph node positive patients.
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