Evidence map›Paper›PMID 38263268›Full record

ArticleHuman genome variation2024

Novel frameshift variant of WNT10A in a Japanese patient with hypodontia.

Michiyo Ando, Yoshihiko Aoki, Yasuto Sano, Junya Adachi, Masatoshi Sana, Satoru Miyabe, Satoshi Watanabe, Shogo Hasegawa, Hitoshi Miyachi, Junichiro Machida and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human genome variation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Michiyo AndoDepartment of Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.ORCID http://orcid.org/0000-0002-7539-4257
Yoshihiko AokiDepartment of Disease Model, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai, Japan.
Yasuto SanoDepartment of Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
Junya AdachiDepartment of Disease Model, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai, Japan.
Masatoshi SanaNagoya Orthodontic Clinic, Nagoya, Japan.
Satoru MiyabeDepartment of Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
Satoshi WatanabeDepartment of Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
Shogo HasegawaDepartment of Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
Hitoshi MiyachiDepartment of Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
Junichiro MachidaDepartment of Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.ORCID http://orcid.org/0000-0002-7128-0527
Mitsuo GotoDepartment of Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
Yoshihito TokitaDepartment of Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan. tokita@inst-hsc.jp.ORCID http://orcid.org/0000-0001-8598-3525
Aichi Gakuin University · JPOkazaki City Hospital · JPToyohashi Municipal Hospital · JP

Funding

Japan Agency for Medical Research and Development (AMED) JP17nk0101334Japan Agency for Medical Research and Development (AMED) JP20ek0109397
6 · The paper itself

Abstract

Congenital tooth agenesis is caused by the impairment of crucial genes related to tooth development, such as Wnt signaling pathway genes. Here, we investigated the genetic causes of sporadic congenital tooth agenesis. Exome sequencing, followed by Sanger sequencing, identified a novel single-nucleotide deletion in WNT10A (NC_000002.12(NM_025216.3):c.802del), which was not found in the healthy parents of the patient. Thus, we concluded that the variant was the genetic cause of the patient's agenesis.

Identifiers

PMID38263268
PMCPMC10806032
OpenAlexW4391142533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.