Evidence map›Paper›PMID 38263253›Full record

ArticleScientific reports2024

Benefits of statin therapy within a year after kidney transplantation.

Seung Hyuk Yim, Hyun Jeong Kim, Han Ro, Jung-Hwa Ryu, Myung-Gyu Kim, Jae Berm Park, Chan-Duck Kim, Seungyeup Han, Sik Lee, Jaesok Yang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Seung Hyuk YimDepartment of Surgery, The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, South Korea.
Hyun Jeong KimDepartment of Surgery, The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, South Korea.
Han RoDepartment of Internal Medicine, Gachon University College of Medicine, Incheon, South Korea.
Jung-Hwa RyuDepartment of Internal Medicine, Ewha Womans University Seoul Hospital, Seoul, South Korea.
Myung-Gyu KimDepartment of Internal Medicine, Korea University College of Medicine, Seoul, South Korea.
Jae Berm ParkDepartment of Surgery, Seoul Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea.
Chan-Duck KimDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, South Korea.
Seungyeup HanDepartment of Internal Medicine, Dongsan Medical Center, Keimyung University, Daegu, South Korea.
Sik LeeDepartment of Internal Medicine, Chonbuk National University Hospital, Jeonju, South Korea.
Jaesok YangDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Kyu Ha HuhDepartment of Surgery, The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, South Korea.
Myoung Soo KimDepartment of Surgery, The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, South Korea.
Juhan LeeDepartment of Surgery, The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, South Korea. laplaine@yuhs.ac.
Yonsei University · KRKorea University · KREwha Womans University · KRGachon University · KRJeonbuk National University Hospital · KRKeimyung University Dongsan Medical Center · KRKyungpook National University Hospital · KRSungkyunkwan University · KR

Funding

Research of Korea Disease Control and Prevention Agency 2012E3301100Research of Korea Disease Control and Prevention Agency 2013E3301600Research of Korea Disease Control and Prevention Agency 2013E3301601Research of Korea Disease Control and Prevention Agency 2013E3301602Research of Korea Disease Control and Prevention Agency 2016E3300200Research of Korea Disease Control and Prevention Agency 2016E3300201Research of Korea Disease Control and Prevention Agency 2016E3300202Research of Korea Disease Control and Prevention Agency 2019E320100Research of Korea Disease Control and Prevention Agency 2019E320101Research of Korea Disease Control and Prevention Agency 2019E320102Research of Korea Disease Control and Prevention Agency 2022-11-007
6 · The paper itself

Abstract

Cardiovascular disease remains a leading cause of morbidity and mortality after kidney transplantation (KT). Although statins reduce cardiovascular risk and have renal benefits in the general population, their effects on KT recipients are not well-established. We studied the effects of early statin use (within 1-year post-transplantation) on long-term outcomes in 714 KT recipients from the Korean cohort study for outcome in patients with KT. Compared with the control group, statin group recipients were significantly older, had a higher body mass index, and had a higher prevalence of diabetes mellitus. During a median follow-up of 85 months, 74 graft losses occurred (54 death-censored graft losses and 20 deaths). Early statin use was independently associated with lower mortality (hazard ratio, 0.280; 95% confidence interval 0.111-0.703) and lower death-censored graft loss (hazard ratio, 0.350; 95% confidence interval 0.198-0.616). Statin therapy significantly reduced low-density lipoprotein cholesterol levels but did not decrease the risk of major adverse cardiovascular events. Biopsy-proven rejection and graft renal function were not significantly different between statin and control groups. Our findings suggest that early statin use is an effective strategy for reducing low-density lipoprotein cholesterol and improving patient and graft survival after KT.

Indexed as

Hydroxymethylglutaryl-CoA Reductase InhibitorsKidney TransplantationCholesterol, LDLCohort StudiesHumansKidneyCholesterol, LDLHydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID38263253
PMCPMC10805738
OpenAlexW4391174323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.