Evidence map›Paper›PMID 38263169›Full record

ArticleNPJ vaccines2024

In vivo assembly of epitope-coated biopolymer particles that induce anti-tumor responses.

Devi Jenika, Saranya Pounraj, David Wibowo, Leonhard M Flaxl, Bernd H A Rehm, Justine D Mintern

Open access · goldAbstract read
In one paragraph

Article in NPJ vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Devi JenikaDepartment of Biochemistry and Pharmacology, The University of Melbourne, Bio21 Molecular Science and Biotechnology Institute, Parkville, VIC, 3010, Australia.
Saranya PounrajCentre for Cell Factories and Biopolymers, Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD, 4111, Australia.
David WibowoCentre for Cell Factories and Biopolymers, Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD, 4111, Australia.
Leonhard M FlaxlDepartment of Biochemistry and Pharmacology, The University of Melbourne, Bio21 Molecular Science and Biotechnology Institute, Parkville, VIC, 3010, Australia.
Bernd H A RehmCentre for Cell Factories and Biopolymers, Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD, 4111, Australia. b.rehm@griffith.edu.au.ORCID http://orcid.org/0000-0003-3908-8903
Justine D MinternDepartment of Biochemistry and Pharmacology, The University of Melbourne, Bio21 Molecular Science and Biotechnology Institute, Parkville, VIC, 3010, Australia. jmintern@unimelb.edu.au.ORCID http://orcid.org/0000-0002-3797-8577
Griffith University · AUThe University of Melbourne · AU

Funding

Department of Education and Training | Australian Research Council (ARC) 160101373Department of Education and Training | Australian Research Council (ARC) 180100521Department of Education and Training | Australian Research Council (ARC) 180100844Department of Education and Training | Australian Research Council (ARC) 190101242Department of Education and Training | Australian Research Council (ARC) DP200100874Department of Education and Training | Australian Research Council (ARC) LE20010014Department of Health | National Health and Medical Research Council (NHMRC) 1129672Department of Health | National Health and Medical Research Council (NHMRC) 1161101
6 · The paper itself

Abstract

There is an unmet need for antigen delivery systems that elicit efficient T cell priming to prevent infectious diseases or for treatment of cancers. Here, we explored the immunogenic potential of biologically assembled biopolymer particles (BPs) that have been bioengineered to display the antigenic MHC I and MHC II epitopes of model antigen ovalbumin (OVA). Purified dendritic cells (DCs) captured BP-OVA and presented the associated antigenic epitopes to CD4

Identifiers

PMID38263169
PMCPMC10805745
OpenAlexW4391130485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.