Observational studyCritical care (London, England)2024
Prognostic evaluation of quick sequential organ failure assessment score in ICU patients with sepsis across different income settings.
Observational study in Critical care (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Article
- Comparative Prognostic Performance of qSOFA and SOFA in Emergency Department Patients With Established Septic Shock.Emergency medicine international · 2026Article
- Observational
- Sleep Quality, Circadian Rhythm Stability and Changes in Delirium State in Predicting Mortality Risk in Intensive Care Unit Patients: A Prospective Observational Study.Nursing in critical care · 2025Observational
- Evaluation of clinical research priorities in Asian intensive care units (ERA-ICU).Journal of intensive care · 2025Article
- Reference values for the 1-minute sit-to-stand test to assess functional capacity and short-term mortality in people with idiopathic pulmonary fibrosis and fibrotic connective tissue related interstitial lung diseases: a prospective real-world cohort study.BMC pulmonary medicine · 2025Article
- Limitation of life-sustaining treatments in Asian ICUs: theory versus practice.Critical care (London, England) · 2025Article
- Construction and validation of nomogram prediction model for clinical efficacy of high-dose continuous renal replacement therapy in sepsis patients based on inflammatory response and microcirculation.Frontiers in medicine · 2025Article
- Association of platelet-to-lymphocyte ratio with 1-year all-cause mortality in ICU patients with heart failure.Scientific reports · 2024Article
- Core sepsis-related competencies for medical students: an international consensus by Delphi technique.BMC medical education · 2024Article
- Reflections on epidemiological investigations of sepsis in the Asian Region.Critical care (London, England) · 2024Article
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Authors and funding
30 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is conflicting evidence on association between quick sequential organ failure assessment (qSOFA) and sepsis mortality in ICU patients. The primary aim of this study was to determine the association between qSOFA and 28-day mortality in ICU patients admitted for sepsis. Association of qSOFA with early (3-day), medium (28-day), late (90-day) mortality was assessed in low and lower middle income (LLMIC), upper middle income (UMIC) and high income (HIC) countries/regions.
methodsThis was a secondary analysis of the MOSAICS II study, an international prospective observational study on sepsis epidemiology in Asian ICUs. Associations between qSOFA at ICU admission and mortality were separately assessed in LLMIC, UMIC and HIC countries/regions. Modified Poisson regression was used to determine the adjusted relative risk (RR) of qSOFA score on mortality at 28 days with adjustments for confounders identified in the MOSAICS II study.
resultsAmong the MOSAICS II study cohort of 4980 patients, 4826 patients from 343 ICUs and 22 countries were included in this secondary analysis. Higher qSOFA was associated with increasing 28-day mortality, but this was only observed in LLMIC (p < 0.001) and UMIC (p < 0.001) and not HIC (p = 0.220) countries/regions. Similarly, higher 90-day mortality was associated with increased qSOFA in LLMIC (p < 0.001) and UMIC (p < 0.001) only. In contrast, higher 3-day mortality with increasing qSOFA score was observed across all income countries/regions (p < 0.001). Multivariate analysis showed that qSOFA remained associated with 28-day mortality (adjusted RR 1.09 (1.00-1.18), p = 0.038) even after adjustments for covariates including APACHE II, SOFA, income country/region and administration of antibiotics within 3 h.
conclusionsqSOFA was independently associated with 28-day mortality in ICU patients admitted for sepsis. In LLMIC and UMIC countries/regions, qSOFA was associated with early to late mortality but only early mortality in HIC countries/regions.
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