Evidence map›Paper›PMID 38262773›Full record

Observational studyOral surgery, oral medicine, oral pathology and oral radiology2024

Reduced mouth opening in patients with head and neck cancer treated with radiation therapy: an analysis of the Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients (OraRad).

Thomas P Sollecito, Erika S Helgeson, Rajesh V Lalla, Nathaniel S Treister, Brian L Schmidt, Lauren L Patton, Alexander Lin, Michael T Brennan

Registry-linked trialOpen access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Oral surgery, oral medicine, oral pathology and oral radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02057510 (Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02057510 completednot on this map

Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients

Typeobservational_patient_registrySponsorWake Forest University Health SciencesRan2014 to 2020Enrolled613ConditionsHead and Neck Cancer, Dental Disease, Xerostomia, Osteoradionecrosis
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Observational
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 1 country.

Thomas P SollecitoDepartment of Oral Medicine, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA; Division of Oral Medicine, University of Pennsylvania Health System, Philadelphia, PA, USA.
Erika S HelgesonDivision of Biostatistics and Health Data Science, University of Minnesota, Minneapolis, MN, USA.
Rajesh V LallaSection of Oral Medicine, University of Connecticut Health, Farmington, CT, USA.
Nathaniel S TreisterDivision of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USA; Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
Brian L SchmidtDepartment of Oral and Maxillofacial Surgery, New York University School of Dentistry, New York, NY, USA.
Lauren L PattonDivision of Craniofacial and Surgical Care, University of North Carolina, Adams School of Dentistry, Chapel Hill, NC, USA.
Alexander LinDepartment of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Michael T BrennanDepartment Oral Medicine/Oral & Maxillofacial Surgery, Atrium Health Carolinas Medical Center, Charlotte, NC, USA.
Brigham and Women's Hospital · USCarolinas Medical Center · USNew York University · USUConn Health · USUniversity of Minnesota · USUniversity of North Carolina at Chapel Hill · USUniversity of Pennsylvania · USUniversity of Pennsylvania Health System · US

Funding

Long-term Oral Complications of an Established Head and Neck Cancer Cohort- Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients: OraRadU01DE022939 · NIDCR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BRENNAN, MICHAEL T, LALLA, RAJESH V. · 2012 to 2023
$16.8M
NIDCR NIH HHS U01 DE022939
6 · The paper itself

Abstract

objectiveTrismus/reduced mouth opening (RMO) is a common side effect of radiotherapy (RT) for head and neck cancer (HNC). The objective was to measure RMO, identify risk factors for RMO, and determine its impact on quality of life (QOL). STUDY

designOraRad is an observational, prospective, multicenter cohort study of patients receiving curative intent RT for HNC. Interincisal mouth opening measurements (n = 565) and patient-reported outcomes were recorded before RT and every 6 months for 2 years. Linear mixed-effects models were used to evaluate change in mouth opening and assess the relationship between trismus history and change in QOL measures.

resultsInterincisal distance decreased from a mean (SE) of 45.1 (0.42) mm at baseline to 42.2 (0.44) at 6 months, with slight recovery at 18 months (43.3, 0.46 mm) but no additional improvement by 24 months. The odds of trismus (opening <35 mm) were significantly higher at 6 months (odds ratio [OR] = 2.21, 95% CI: 1.30 to 3.76) and 12 months (OR = 1.87, 95% CI: 1.08 to 3.25) compared with baseline. Females were more likely to experience trismus at baseline and during follow-up (P < .01). Patients with oral cavity cancer had the highest risk for trismus at baseline and post-RT (P < .01). RMO was associated with higher RT dose to the primary site and receiving concomitant chemotherapy (P < .01). Trismus was associated with self-reported difficulty opening the mouth and dry mouth (P < .01).

conclusionsA decrease in mouth opening is a common treatment-related toxicity after RT, with some recovery by 18 months. Trismus has a significant impact on survivor QOL.

Indexed as

Head and Neck NeoplasmsTrismusCohort StudiesFemaleHumansMaleMouthProspective StudiesQuality of LifeRegistries

Identifiers

PMID38262773
PMCPMC10922984
OpenAlexW4389010938

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.