Evidence map›Paper›PMID 38262742›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2024

Effects of Repeated Treatment with the Monoacylglycerol Lipase Inhibitor MJN110 on Pain-Related Depression of Nesting and Cannabinoid 1 Receptor Function in Male and Female Mice.

Clare M Diester, Hallie Balint, James C Gillespie, Aron H Lichtman, Laura J Sim-Selley, Dana E Selley, S Stevens Negus

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Clare M DiesterDepartment of Pharmacology and Toxicology (C.M.D., H.B., J.C.G., A.H.L., L.J.S.-S., D.E.S., S.S.N.) and School of Pharmacy (A.H.L.), Virginia Commonwealth University, Richmond, Virginia.ORCID 0000-0003-3753-2492
Hallie BalintDepartment of Pharmacology and Toxicology (C.M.D., H.B., J.C.G., A.H.L., L.J.S.-S., D.E.S., S.S.N.) and School of Pharmacy (A.H.L.), Virginia Commonwealth University, Richmond, Virginia.
James C GillespieDepartment of Pharmacology and Toxicology (C.M.D., H.B., J.C.G., A.H.L., L.J.S.-S., D.E.S., S.S.N.) and School of Pharmacy (A.H.L.), Virginia Commonwealth University, Richmond, Virginia.
Aron H LichtmanDepartment of Pharmacology and Toxicology (C.M.D., H.B., J.C.G., A.H.L., L.J.S.-S., D.E.S., S.S.N.) and School of Pharmacy (A.H.L.), Virginia Commonwealth University, Richmond, Virginia.
Laura J Sim-SelleyDepartment of Pharmacology and Toxicology (C.M.D., H.B., J.C.G., A.H.L., L.J.S.-S., D.E.S., S.S.N.) and School of Pharmacy (A.H.L.), Virginia Commonwealth University, Richmond, Virginia.
Dana E SelleyDepartment of Pharmacology and Toxicology (C.M.D., H.B., J.C.G., A.H.L., L.J.S.-S., D.E.S., S.S.N.) and School of Pharmacy (A.H.L.), Virginia Commonwealth University, Richmond, Virginia.ORCID 0000-0003-3118-9339
S Stevens NegusDepartment of Pharmacology and Toxicology (C.M.D., H.B., J.C.G., A.H.L., L.J.S.-S., D.E.S., S.S.N.) and School of Pharmacy (A.H.L.), Virginia Commonwealth University, Richmond, Virginia sidney.negus@vcuhealth.org.

Funding

VCU Center for Drug Addiction ResearchP30DA033934 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI ARON H LICHTMAN · 2014 to 2026
$13.8M
Mechanisms and treatment of pain-depressed behaviorF31DA051163 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DIESTER, CLARE · 2020 to 2021
$70k
NIDA NIH HHS F31 DA051163NIDA NIH HHS P30 DA033934
6 · The paper itself

Abstract

MJN110 inhibits the enzyme monoacylglycerol lipase (MAGL) to increase levels of the endocannabinoid 2-arachidonoylglycerol , an endogenous high-efficacy agonist of cannabinoid 1 and 2 receptors (CB

Indexed as

Mice, Inbred ICRMonoacylglycerol LipasesPainReceptor, Cannabinoid, CB1AnalgesicsAnimalsBenzeneacetamidesCarbamatesDepressionEnzyme InhibitorsFemaleMaleMiceNesting BehaviorSuccinimidesAnalgesicsBenzeneacetamidesCarbamatesEnzyme InhibitorsMJN110Monoacylglycerol LipasesReceptor, Cannabinoid, CB1Succinimides

Identifiers

PMID38262742
PMCPMC11338278

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.