Evidence map›Paper›PMID 38262670›Full record

SynthesisBMJ open respiratory research2024

Impact of different corticosteroids on severe community-acquired pneumonia: a systematic review and meta-analysis.

Xin Ya See, Tsu Hsien Wang, Yu-Cheng Chang, Juien Lo, Weitao Liu, Cheryn Yu Wei Choo, Yu-Che Lee, Kevin Sheng Kai Ma, Cho-Hsien Chiang, Yuan Ping Hsia and 2 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ open respiratory research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.

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  14. Steroids in severe community-acquired pneumonia.Breathe (Sheffield, England) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 3 countries.

Xin Ya See *Department of Medicine, Unity Hospital, Rochester Regional Health, Rochester, New York, USA.
Tsu Hsien Wang *Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Foundation, New Taipei City, Taiwan.
Yu-Cheng Chang *Department of Medicine, Danbury Hospital, Danbury, Connecticut, USA.
Juien LoDepartment of Medicine, University of California San Diego, San Diego, California, USA.
Weitao LiuDepartment of Medicine, Yale New Haven Hospital, New Haven, Connecticut, USA.
Cheryn Yu Wei ChooDepartment of Internal Medicine, Singapore Health Services, Singapore.
Yu-Che LeeDivision of Pulmonary, Critical Care and Sleep Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.
Kevin Sheng Kai MaDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Cho-Hsien ChiangDepartment of Environmental and Occupational Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Yuan Ping HsiaDepartment of Family Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Foundation, New Taipei City, Taiwan ustwhealth.datascience.group@gmail.com.ORCID 0000-0002-8759-3093
Cho-Hung ChiangDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Cho-Han ChiangDepartment of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, Massachusetts, USA.
Mount Auburn Hospital · USTzu Chi Foundation · TWDanbury Hospital · USHarvard University · USSingHealth · SGUnity Health System · USUniversity at Buffalo, State University of New York · USUniversity of California San Diego · USYale New Haven Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesRandomised controlled trials (RCTs) have demonstrated conflicting results regarding the effects of corticosteroids on the treatment of severe community-acquired pneumonia (CAP). We aimed to investigate the efficacy and safety of different corticosteroids on patients who were hospitalised for severe CAP.

methodsWe performed a systematic search through PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and Scopus from inception to May 2023. The primary outcome was all-cause mortality. Data analysis was performed using a random-effects model.

resultsA total of 10 RCTs comprising 1962 patients were included. Corticosteroids were associated with a lower rate of all-cause mortality (risk ratio (RR), 0.70 (95% CI 0.54 to 0.90); I

conclusionsThe use of hydrocortisone, but not other types of corticosteroids, was associated with a reduction in mortality and improvement in pneumonia outcomes among patients hospitalised with severe CAP.PROSPERO registration numberCRD42023431360.

Indexed as

Community-Acquired InfectionsPneumoniaAdrenal Cortex HormonesDexamethasoneHumansHydrocortisoneMethylprednisoloneAdrenal Cortex HormonesDexamethasoneHydrocortisoneMethylprednisoloneCritical CarePneumoniaRespiratory Infection

Identifiers

PMID38262670
PMCPMC10806634
OpenAlexW4391146398

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.