Evidence map›Paper›PMID 38262663›Full record

ArticleBMJ (Clinical research ed.)2024

The estimands framework: a primer on the ICH E9(R1) addendum.

Brennan C Kahan, Joanna Hindley, Mark Edwards, Suzie Cro, Tim P Morris

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ (Clinical research ed.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  7. Efficacy of up to 4 years of tralokinumab in adults with moderate-to-severe atopic dermatitis.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Brennan C KahanMRC Clinical Trials Unit at UCL, University College London, London WC1V 6LJ, UK.ORCID 0000-0001-9957-0844
Joanna HindleyMRC Clinical Trials Unit at UCL, University College London, London WC1V 6LJ, UK.
Mark EdwardsDepartment of Anaesthesia, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Suzie CroImperial Clinical Trials Unit, School of Public Health, Imperial College London, London, UK.
Tim P MorrisMRC Clinical Trials Unit at UCL, University College London, London WC1V 6LJ, UK.

Funding

Medical Research Council MC_UU_00004/07Medical Research Council MC_UU_00004/09Medical Research Council MR/S014357/1
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Models, StatisticalResearch DesignHumans

Identifiers

PMID38262663
PMCPMC10802140

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.