ArticleEnvironmental health perspectives2024
Associations of Organophosphate Ester Flame Retardant Exposures during Pregnancy with Gestational Duration and Fetal Growth: The Environmental influences on Child Health Outcomes (ECHO) Program.
Erratum issuedOpen access · diamondAbstract read
In one paragraph
Article in Environmental health perspectives, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Prenatal exposure to organophosphate ester flame retardants and plasticizers and maternal immune responses in three ECHO cohorts.Environmental research · 2026Article
- Gestational exposure to organophosphate ester flame retardants and child growth in weight, height, and body mass index at age 2-10 years: the Environmental influences on Child Health Outcomes Program.Environmental research · 2026Article
- Association between volatile organic compound concentrations in daycares and child wheeze: the French CRESPI study.Environmental health : a global access science source · 2026Article
- Nontargeted screening identifies mixtures of environmental pollutants that are associated with perturbations to amino acid and fatty acid metabolic pathways during early pregnancy.Environment international · 2026Article
- Prenatal exposure to organophosphate ester flame retardants and child cognition: Findings from the environmental influences on child Health Outcomes cohort.Environmental pollution (Barking, Essex : 1987) · 2026Article
- Prenatal phthalate exposure and neurodevelopmental delay in early childhood (1 to 3 years): An Environmental influences on Child Health Outcomes (ECHO) study.Environment international · 2026Article
- Flame retardant biomarker changes with furniture replacement after flammability standard update.Environmental pollution (Barking, Essex : 1987) · 2026Article
- Analysis of Human Placental Tissues Using Gas Chromatography High Resolution Accurate Mass Spectrometry to Characterize Exposure to a Range of Semivolatile Organic Compounds.Exposure and health · 2026Article
- Organophosphate ester exposure in pregnancy, gestational weight gain, and postpartum body composition in a U.S.-based longitudinal pregnancy cohort.Environmental health : a global access science source · 2025Article
- Prenatal exposure to environmental phenolic compounds and their association with childhood atopic dermatitis, asthma, and allergic rhinitis in the ECHO cohort.Environment international · 2025Article
- Prenatal organophosphate ester exposure and epigenetic changes at birth: a characterization of the methylome in the ECHO cohort.Environment international · 2025Article
- Associations between brominated and organophosphate flame retardant levels and inflammatory biomarkers in maternal blood, cord blood, and placental tissue at mid-gestation.The Science of the total environment · 2025Article
- Prenatal exposure to organophosphate ester flame retardants and behavioral outcomes in early childhood in the Environmental influences on Child Health Outcomes (ECHO) cohort.Environment international · 2025Article
- Maternal organophosphate esters and sex steroid hormones in mid-pregnancy.Environmental research · 2025Article
- An assessment of organophosphate ester mixtures and the placental transcriptome.Environment international · 2025Article
- Gestational exposure to organophosphate esters and autism spectrum disorder and other non-typical development in a cohort with elevated familial likelihood.Environmental research · 2024Article
- Gestational exposure to organophosphate ester flame retardants and risk of childhood obesity in the environmental influences on child health outcomes consortium.Environment international · 2024Article
- Regrettable Substitution? Organophosphate Flame Retardants and Macrophage Activity.Environmental health perspectives · 2024Article
- Urinary Concentrations of Organophosphate Flame-Retardant Metabolites in the US Population.JAMA network open · 2024Article
- Advancing Understanding of Chemical Exposures and Maternal-child Health Through the U.S. Environmental Influences on Child Health Outcomes (ECHO) Program: A Scoping Review.Current environmental health reports · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
37 authors at 20 institutions in 2 countries.
Jiwon OhDepartment of Public Health Sciences, University of California Davis (UC-Davis), Davis, California, USA.
Jessie P BuckleyDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Xuan LiDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Kennedy K GachigiDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Kurunthachalam KannanWadsworth Center, Division of Environmental Health Sciences, New York State Department of Health, Albany, New York, USA.
Wenjie LyuDepartment of Pediatrics, New York University (NYU) Grossman School of Medicine, New York, New York, USA.
Jennifer L AmesDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Emily S BarrettDepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey, USA.
Theresa M BastainDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA.
Carrie V BretonDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA.
Claudia BussDepartment of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Lisa A CroenDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Anne L DunlopDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Assiamira FerraraDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Akhgar GhassabianDepartment of Pediatrics, New York University (NYU) Grossman School of Medicine, New York, New York, USA.
Julie B HerbstmanDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USA.
Ixel Hernandez-CastroDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA.
Irva Hertz-PicciottoDepartment of Public Health Sciences, University of California Davis (UC-Davis), Davis, California, USA.
Linda G KahnDepartment of Pediatrics, New York University (NYU) Grossman School of Medicine, New York, New York, USA.
Margaret R KaragasDepartment of Epidemiology, Dartmouth Geisel School of Medicine, Lebanon, New Hampshire, USA.
Jordan R KuiperDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Cindy T McEvoyDepartment of Pediatrics, Oregon Health & Science University, Portland, Oregon, USA.
John D MeekerDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Rachel Morello-FroschDepartment of Environmental Science, Policy and Management and School of Public Health, UC-Berkeley, Berkeley, California, USA.
Amy M PadulaProgram on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California, USA.
Megan E RomanoDepartment of Epidemiology, Dartmouth Geisel School of Medicine, Lebanon, New Hampshire, USA.
Sheela SathyanarayanaDepartment of Pediatrics, University of Washington and Seattle Children's Research Institute, Seattle, Washington, USA.
Susan SchantzBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Rebecca J SchmidtDepartment of Public Health Sciences, University of California Davis (UC-Davis), Davis, California, USA.
Hyagriv SimhanDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Anne P StarlingDepartment of Epidemiology, Gillings School of Global Public Health, UNC-Chapel Hill, Chapel Hill, North Carolina, USA.
Frances A TylavskyDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Heather E VolkDepartment of Mental Health, Johns Hopkins University, Baltimore, Maryland, USA.
Tracey J WoodruffProgram on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California, USA.
Yeyi ZhuDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Deborah H BennettDepartment of Public Health Sciences, University of California Davis (UC-Davis), Davis, California, USA.ORCID 0000-0001-6698-2316
program collaborators for Environmental influences on Child Health Outcomes
Johns Hopkins University · USKaiser Permanente · USNew York University · USUniversity of Southern California · USDartmouth College · USNeuroDevelopment Center · USUniversity of California, Davis · USUniversity of California, San Francisco · USUniversity of North Carolina at Chapel Hill · USAlbany State University · USBerkeley Public Health Division · USColumbia University · USEmory University · USOregon Health & Science University · USRutgers, The State University of New Jersey · USSeattle Children's Hospital · USUniversity of California, Irvine · USUniversity of Illinois Urbana-Champaign · USUniversity of Michigan · USUniversity of Pittsburgh · US
Funding
Project-005U2COD023375 · OD · DUKE UNIVERSITY · PI Phillip Brian Smith · 2016 to 2026
$215.9MECHODAC (Environmental Influences on Child Health Outcomes Data Analysis Center)U24OD023382 · OD · JOHNS HOPKINS UNIVERSITY · PI Diane J Catellier, LISA P JACOBSON · 2016 to 2026
$148.4MThe NYU Children’s Health & Environment Study: an ECHO CohortUH3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Akhgar Ghassabian, Leonardo Trasande · 2018 to 2026
$59.5MTranslational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4MTranslational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4MA prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort StudyUH3OD023275 · OD · DARTMOUTH COLLEGE · PI MARGARET Rita KARAGAS, Juliette Madan · 2018 to 2026
$44.3MThe ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child HealthU24OD023319 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Courtney K Blackwell, RICHARD GERSHON · 2016 to 2026
$43.7MPrenatal and Early Childhood Pathways To Health: An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3MLifecourse Approach to Developmental Repercussions of Environmental Agents on Metabolic and Respiratory Health (LA DREAMERs)UH3OD023287 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M, BRETON, CARRIE VAN DOREN · 2018 to 2022
$28.4MUC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Irva Hertz-Picciotto · 2015 to 2026
$26.0MEarly Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and NeurodevelopmentUH3OD023289 · OD · KAISER FOUNDATION RESEARCH INSTITUTE · PI ASSIAMIRA FERRARA, Monique Marie Hedderson · 2018 to 2026
$25.1MNICHD NIH HHS R01 HD083369NIEHS NIH HHS P01 ES022841NIEHS NIH HHS P30 ES005022NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30 ES017885NIEHS NIH HHS P30 ES023513NIEHS NIH HHS P30 ES030284NIEHS NIH HHS P50 ES026086NIEHS NIH HHS R01 ES027051NIEHS NIH HHS R24 ES029490NIEHS NIH HHS U24 ES028533NIEHS NIH HHS U2C ES026542NIGMS NIH HHS P20 GM104416NIH HHS U24 OD023319NIH HHS U24 OD023382NIH HHS U2C OD023375NIH HHS UG3 OD023272NIH HHS UG3 OD023275NIH HHS UG3 OD023289NIH HHS UG3 OD023365NIH HHS UG3 OD035540NIH HHS UH3 OD023248NIH HHS UH3 OD023271NIH HHS UH3 OD023272NIH HHS UH3 OD023275NIH HHS UH3 OD023286NIH HHS UH3 OD023287NIH HHS UH3 OD023288NIH HHS UH3 OD023289NIH HHS UH3 OD023290NIH HHS UH3 OD023305NIH HHS UH3 OD023318NIH HHS UH3 OD023342NIH HHS UH3 OD023349NIH HHS UH3 OD023365NIMHD NIH HHS L60 MD001570NINR NIH HHS R01 NR014800
Abstract
backgroundWidespread exposure to organophosphate ester (OPE) flame retardants with potential reproductive toxicity raises concern regarding the impacts of gestational exposure on birth outcomes. Previous studies of prenatal OPE exposure and birth outcomes had limited sample sizes, with inconclusive results.
objectivesWe conducted a collaborative analysis of associations between gestational OPE exposures and adverse birth outcomes and tested whether associations were modified by sex.
methodsWe included 6,646 pregnant participants from 16 cohorts in the Environmental influences on Child Health Outcomes (ECHO) Program. Nine OPE biomarkers were quantified in maternal urine samples collected primarily during the second and third trimester and modeled as
resultsThree OPE biomarkers [diphenyl phosphate (DPHP), a composite of dibutyl phosphate and di-isobutyl phosphate (DBUP/DIBP), and bis(1,3-dichloro-2-propyl) phosphate] were detected in DISCUSSION: In the largest study to date, we find gestational exposures to several OPEs are associated with earlier timing of birth, especially among female neonates, or with greater fetal growth. https://doi.org/10.1289/EHP13182.
Indexed as
Biphenyl CompoundsFlame RetardantsPremature BirthBiomarkersBirth WeightChildEstersFemaleFetal DevelopmentHumansInfant, NewbornOrganophosphatesOutcome Assessment, Health CarePhosphatesPregnancyBiomarkersbiphenylBiphenyl CompoundsEstersFlame RetardantsOrganophosphatesPhosphates
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.