Evidence map›Paper›PMID 38262603›Full record

ArticleOpen biology2024

A critical threshold of MCM10 is required to maintain genome stability during differentiation of induced pluripotent stem cells into natural killer cells.

Megan M Schmit, Ryan M Baxley, Liangjun Wang, Peter Hinderlie, Marissa Kaufman, Emily Simon, Anjali Raju, Jeffrey S Miller, Anja-Katrin Bielinsky

Open access · goldAbstract read
In one paragraph

Article in Open biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Megan M SchmitDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Ryan M BaxleyDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Liangjun WangDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Peter HinderlieDivision of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN, USA.
Marissa KaufmanDivision of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN, USA.
Emily SimonDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Anjali RajuDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Jeffrey S MillerDivision of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN, USA.
Anja-Katrin BielinskyDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0003-1783-619X
University of Minnesota · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Timothy C. Hallstrom · 1998 to 2026
$100.4M
Therapeutic Potential of Adaptive NK Cells in Cancer and TransplantationP01CA111412 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MILLER, JEFFREY S. · 2005 to 2025
$38.2M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008244 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI SHIMIZU, YOJI · 1988 to 2024
$13.6M
Targeting off-the-shelf iPSC-derived natural killer cells against solid tumorsR35CA283892 · NCI · UNIVERSITY OF MINNESOTA · PI Jeffrey S. Miller · 2023 to 2026
$3.7M
The role of DNA damage tolerance pathways in human cellsR01GM134681 · NIGMS · UNIVERSITY OF VIRGINIA · PI George Lucian Moldovan, Claudia M Nicolae · 2019 to 2026
$3.0M
Mechanistic insight into genome stability pathwaysR35GM141805 · NIGMS · UNIVERSITY OF VIRGINIA · PI Anja-Katrin Bielinsky · 2021 to 2026
$2.9M
NCATS NIH HHS UL1 TR002494NCI NIH HHS P01 CA111412NCI NIH HHS P30 CA077598NCI NIH HHS R35 CA283892NIGMS NIH HHS R01 GM134681NIGMS NIH HHS R35 GM141805NIGMS NIH HHS T32 GM008244
6 · The paper itself

Abstract

Natural killer (NK) cell deficiency (NKD) is a rare disease in which NK cell function is reduced, leaving affected individuals susceptible to repeated viral infections and cancer. Recently, a patient with NKD was identified carrying compound heterozygous variants of

Indexed as

Induced Pluripotent Stem CellsCell DifferentiationGenes, EssentialGenomic InstabilityHumansKiller Cells, NaturalMinichromosome Maintenance ProteinsMCM10 protein, humanMinichromosome Maintenance ProteinsDNA replicationinduced pluripotent stem cellsMCM10natural killer cellstelomeres

Identifiers

PMID38262603
PMCPMC10805602
OpenAlexW4391151810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.