Evidence map›Paper›PMID 38262559›Full record

ArticleJournal of substance use and addiction treatment2024

Medications for opioid use disorder associated with reduced readmissions for patients with severe injection-related infections: A matched cohort study.

Nicole M Robertson, Anthony A Mangino, Anna-Maria South, Laura C Fanucchi

Open access · greenAbstract read
In one paragraph

Article in Journal of substance use and addiction treatment, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nicole M RobertsonDepartment of Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Anthony A ManginoDepartment of Biostatistics, University of Kentucky, Lexington, KY, USA.
Anna-Maria SouthDivision of Hospital Medicine, Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY, USA.
Laura C FanucchiDivision of Infectious Diseases, Department of Internal Medicine, Center on Drug and Alcohol Research, University of Kentucky College of Medicine, Lexington, KY, USA. Electronic address: laura.fanucchi@uky.edu.
University of Kentucky · USJohns Hopkins University · US

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
DAT- Integrated Outpatient Treatment of Opioid Use Disorder and Injection-Related InfectionsR01DA048892 · NIDA · UNIVERSITY OF KENTUCKY · PI FANUCCHI, LAURA, LOFWALL, MICHELLE RENEE · 2020 to 2023
$2.8M
NCATS NIH HHS UL1 TR001998NIDA NIH HHS R01 DA048892
6 · The paper itself

Abstract

introductionHospitalizations due to severe injection-related infections (SIRIs) and patient-directed discharge (PDD) in people who inject drugs (PWID) are increasing, but research on readmission outcomes at PDD is limited. In this retrospective, matched cohort study we evaluated predictors of 30-day readmission by discharge status among PWID.

methodsAmong patients diagnosed with SIRIs at a tertiary hospital, Fisher's exact tests assessed differences in readmission rates by discharge status. Medications for opioid use disorder (MOUD) at discharge was defined as either having a buprenorphine dose dispensed within 24 h of discharge and buprenorphine being included in the discharge summary as a prescription, or a methadone dose dispensed inpatient within 24 h of discharge. Logistic regression analyses evaluated predictors of readmission outcomes.

resultsAmong 148 PWID with SIRI diagnosis, 30-day readmission rate following PDD was higher than standard discharge (25.7 % vs. 9.5 %, p = 0.016) and MOUD decreased odds of 30-day readmission (OR = 0.32, 95 % CI: 0.12,0.83, p = 0.012). >7 missed days of antibiotic treatment increased odds of 30-day readmission (OR 4.65, 95 % CI: 1.14, 31.72, p = 0.030) within PDD patients.

conclusionsPDD carries higher 30-day readmission rate compared to standard discharge. Strategies to reduce PDD rates and increase MOUD initiation may improve readmission outcomes.

Indexed as

BuprenorphineMethadoneOpioid-Related DisordersPatient ReadmissionSubstance Abuse, IntravenousAdultCohort StudiesFemaleHumansMaleMiddle AgedOpiate Substitution TreatmentPatient DischargeRetrospective StudiesBuprenorphineMethadoneAddictionInjection drug useOpioid use disorderPatient directed dischargeReadmissionSevere injection-related infection

Identifiers

PMID38262559
PMCPMC11060916
OpenAlexW4391061902

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.