Evidence map›Paper›PMID 38262418›Full record

ArticleCurrent biology : CB2024

Causal oscillations in the visual thalamo-cortical network in sustained attention in ferrets.

Wei A Huang, Zhe C Zhou, Iain M Stitt, Nivetha S Ramasamy, Susanne Radtke-Schuller, Flavio Frohlich

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Wei A HuangDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA; Carolina Center for Neurostimulation, University of North Carolina, Chapel Hill, NC 27599, USA; Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.
Zhe C ZhouDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA; Carolina Center for Neurostimulation, University of North Carolina, Chapel Hill, NC 27599, USA; Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.
Iain M StittDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA.
Nivetha S RamasamyDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA; Carolina Center for Neurostimulation, University of North Carolina, Chapel Hill, NC 27599, USA.
Susanne Radtke-SchullerDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA; Carolina Center for Neurostimulation, University of North Carolina, Chapel Hill, NC 27599, USA.
Flavio FrohlichDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA; Carolina Center for Neurostimulation, University of North Carolina, Chapel Hill, NC 27599, USA; Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Neurology, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: flavio_frohlich@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Causal investigation of the functional interactions of theta and alpha neural oscillations in output-gatingR01MH124387 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FROHLICH, FLAVIO · 2021 to 2025
$3.4M
Rational Optimization of tACS for Targeting Thalamo-Cortical OscillationsR01MH111889 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FROHLICH, FLAVIO · 2016 to 2019
$2.4M
Targeted circuit modulation to delineate the causal role of oscillatory interactions in top-down networks of cognitive controlR01MH122477 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FROHLICH, FLAVIO · 2020 to 2024
$1.9M
Causal role of higher-order thalamo-cortical oscillations in sustained attentionF31MH118799 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HUANG, WEI · 2019 to 2021
$110k
NIMH NIH HHS F31 MH118799NIMH NIH HHS R01 MH111889NIMH NIH HHS R01 MH122477NIMH NIH HHS R01 MH124387
6 · The paper itself

Abstract

Sustained visual attention allows us to process and react to unpredictable, behaviorally relevant sensory input. Sustained attention engages communication between the higher-order visual thalamus and its connected cortical regions. However, it remains unclear whether there is a causal relationship between oscillatory circuit dynamics and attentional behavior in these thalamo-cortical circuits. By using rhythmic optogenetic stimulation in the ferret, we provide causal evidence that higher-order visual thalamus coordinates thalamo-cortical and cortico-cortical functional connectivity during sustained attention via spike-field phase locking. Increasing theta but not alpha power in the thalamus improved accuracy and reduced omission rates in a sustained attention task. Further, the enhancement of effective connectivity by stimulation was correlated with improved behavioral performance. Our work demonstrates a potential circuit-level causal mechanism for how the higher-order visual thalamus modulates cortical communication through rhythmic synchronization during sustained attention.

Indexed as

FerretsVisual CortexAnimalsThalamusanimal behaviorcausal manipulationfrequency specificfunctional connectivityoptogenetic stimulationOscillationsposterior visual networksustained attentionthalamo-cortical network

Identifiers

PMID38262418
PMCPMC10922762
OpenAlexW4391112827

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.