ArticleNeuron2024
Mapping of multiple neurotransmitter receptor subtypes and distinct protein complexes to the connectome.
Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 26 citations in OpenAlex.
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- Motor neurons integrate cholinergic inputs through spatial organization of diverse nicotinic receptors.PNAS nexus · 2026Article
- Homotypic dendritic interactions constrain growth and receptor distribution in Drosophila T4 neurons without affecting orientation or function.Development (Cambridge, England) · 2026Article
- Glutamate receptor composition atbioRxiv : the preprint server for biology · 2026Article
- Hormonal control of postmitotic neuronal identity.bioRxiv : the preprint server for biology · 2026Article
- Convergence-divergence circuits for multimodal integration of innate and learned opponent valences.Frontiers in systems neuroscience · 2026Article
- Visual input drives diverse ER calcium signals in neuronsbioRxiv : the preprint server for biology · 2025Article
- dFlpTag, a RMCE-based tool for simultaneous endogenous protein tagging and cell labeling in Drosophila.Scientific reports · 2025Article
- FETCH enables fluorescent labeling of membrane proteins in vivo with spatiotemporal control inProceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Multimerized epitope tags for high-sensitivity protein detection.G3 (Bethesda, Md.) · 2025Article
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- Molecular organization of central cholinergic synapses.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Gradients of Cell Recognition Molecules Wire Visuomotor Transformation.bioRxiv : the preprint server for biology · 2025Article
- Synaptic enrichment and dynamic regulation of the two opposing dopamine receptors within the same neurons.eLife · 2025Article
- Rapid lightsheet fluorescence imaging of whole Drosophila brains at nanoscale resolution by potassium acrylate-based expansion microscopy.Nature communications · 2024Article
- Plant BCL-Domain Homologues play a conserved role in SWI/SNF complex stability.bioRxiv : the preprint server for biology · 2024Article
- Constitutive and Conditional Epitope Tagging of Endogenous G-Protein-Coupled Receptors inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
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14 authors at 3 institutions in 1 country.
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Abstract
Neurons express various combinations of neurotransmitter receptor (NR) subunits and receive inputs from multiple neuron types expressing different neurotransmitters. Localizing NR subunits to specific synaptic inputs has been challenging. Here, we use epitope-tagged endogenous NR subunits, expansion light-sheet microscopy, and electron microscopy (EM) connectomics to molecularly characterize synapses in Drosophila. We show that in directionally selective motion-sensitive neurons, different multiple NRs elaborated a highly stereotyped molecular topography with NR localized to specific domains receiving cell-type-specific inputs. Developmental studies suggested that NRs or complexes of them with other membrane proteins determine patterns of synaptic inputs. In support of this model, we identify a transmembrane protein selectively associated with a subset of spatially restricted synapses and demonstrate its requirement for synapse formation through genetic analysis. We propose that mechanisms that regulate the precise spatial distribution of NRs provide a molecular cartography specifying the patterns of synaptic connections onto dendrites.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.