Evidence map›Paper›PMID 38262393›Full record

ArticleAllergy, asthma & immunology research2024

Suppression of SPARC Ameliorates Ovalbumin-induced Airway Remodeling via TGFβ1/Smad2 in Chronic Asthma.

Yun Pan, Dong Zhang, Jintao Zhang, Xiaofei Liu, Jiawei Xu, Rong Zeng, Wenjing Cui, Tian Liu, Junfei Wang, Liang Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, asthma & immunology research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yun PanDepartment of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.ORCID https://orcid.org/0000-0002-5014-0322
Dong ZhangDepartment of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.ORCID https://orcid.org/0000-0001-7323-7699
Jintao ZhangDepartment of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.ORCID https://orcid.org/0000-0002-1309-6836
Xiaofei LiuDepartment of Respiratory, Shandong Provincial Qianfoshan Hospital, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.ORCID https://orcid.org/0000-0002-7285-7578
Jiawei XuDepartment of Respiratory and Intensive Care Unit, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Jinan, China.ORCID https://orcid.org/0000-0002-6289-5589
Rong ZengDepartment of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.ORCID https://orcid.org/0000-0003-1320-8815
Wenjing CuiDepartment of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.ORCID https://orcid.org/0000-0003-1308-1404
Tian LiuDepartment of Pulmonary and Critical Medicine, Qilu Hospital of Shandong University, Jinan, China.
Junfei WangDepartment of Pulmonary and Critical Medicine, Qilu Hospital of Shandong University, Jinan, China.ORCID https://orcid.org/0009-0007-1960-5957
Liang DongDepartment of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.ORCID https://orcid.org/0000-0001-7707-9982

Funding

Jinan Clinical Medicine Research Program for Respiratory Disease 202132002Key Technology Research and Development Program of Shandong 2021SFGC0504National Natural Science Foundation of China 82270032Natural Science Foundation of Shandong Provincial ZR2021LSW015Natural Science Foundation of Shandong Provincial ZR2022QH235
6 · The paper itself

Abstract

purposeAirway remodeling is a critical feature of asthma. Secreted protein acidic and rich in cysteine (SPARC), which plays a cardinal role in regulating cell-matrix interactions, has been implicated in various fibrotic diseases. However, the effect of SPARC in asthma remains unknown.

methodsWe studied the expression of SPARC in human bronchial epithelial cells and serum of asthmatics as well as in the lung tissues of chronic asthma mice. The role of SPARC was examined by using a Lentivirus-mediated SPARC knockdown method in the ovalbumin (OVA)-induced asthma mice. The biological processes regulated by SPARC were identified using RNA sequencing. The function of SPARC in the remodeling process induced by transforming growth factor β1 (TGFβ1) was conducted by using SPARC small interfering RNA (siRNA) or recombinant human SPARC protein in 16HBE cells.

resultsWe observed that SPARC was up-regulated in human bronchial epithelia of asthmatics and the asthmatic mice. The levels of serum SPARC in asthmatics were also elevated and negatively correlated with the forced expiratory volume in one second (FEV1) to forced vital capacity ratio (FVC) (

conclusionsOur studies provided evidence for the involvement of SPARC in the airway remodeling of asthma via the TGFβ1/Smad2 pathway.

Indexed as

airway remodelingAsthmaextracellular matrixSPARCtherapy, lung function

Identifiers

PMID38262393
PMCPMC10823139

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.