Evidence map›Paper›PMID 38262392›Full record

ArticleAllergy, asthma & immunology research2024

LincR-PPP2R5C Promotes Th2 Cell Differentiation Through PPP2R5C/PP2A by Forming an RNA-DNA Triplex in Allergic Asthma.

Ningfei Ji, Zhongqi Chen, Zhengxia Wang, Wei Sun, Qi Yuan, Xijie Zhang, Xinyu Jia, Jingjing Wu, Jingxian Jiang, Meijuan Song and 7 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, asthma & immunology research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Ningfei Ji *Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0002-5044-2240
Zhongqi Chen *Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0003-1908-5262
Zhengxia Wang *Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0003-1325-124X
Wei Sun *Department of Respiratory and Critical Care Medicine, Xishan People's Hospital of Wuxi City, Wuxi Branch of Zhongda Hospital Affiliate to Southeast University, Wuxi, China.ORCID https://orcid.org/0009-0008-4178-8494
Qi YuanDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0009-0008-7985-9235
Xijie ZhangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0009-0009-9946-9784
Xinyu JiaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0002-1832-9504
Jingjing WuDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0009-0006-0206-7876
Jingxian JiangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0009-0007-6566-1001
Meijuan SongDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0002-1244-0375
Tingting XuDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0001-9892-7952
Yanan LiuDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0002-6327-344X
Qiyun MaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0002-3726-5147
Zhixiao SunDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0002-7364-235X
Yanmin BaoDepartment of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, China.ORCID https://orcid.org/0000-0003-2610-2542
Mingshun ZhangJiangsu Province Engineering Research Center of Antibody Drugs, NHC Key Laboratory of Antibody Technique, Department of Immunology, Nanjing Medical University, Nanjing, China. mingshunzhang@njmu.edu.cn.ORCID https://orcid.org/0000-0001-5925-0168
Mao HuangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. hm6114@163.com.ORCID https://orcid.org/0000-0002-2743-1017
Jiangsu Province Hospital · CNNanjing Medical University · CNShenzhen Children's Hospital · CNWuxi People's Hospital · CN

Funding

Jiangsu Province's Young Medical Talent Program QNRC2016600Jiangsu Provincial Health and Family Planning Commission Foundation Q2017001National Natural Science Foundation of China 81671563National Natural Science Foundation of China 81770031National Natural Science Foundation of China 81970031National Natural Science Foundation of China 82171738Natural Science Foundation of Jiangsu Province BK2017080Natural Science Foundation of Jiangsu Province BK20171501Natural Science Foundation of Jiangsu Province BK20181497Precision Medicine Research of the National Key Research and Development Plan of China 2016YFC0905800
6 · The paper itself

Abstract

purposeThe roles and mechanisms of long noncoding RNAs (lncRNAs) in T helper 2 (Th2) differentiation from allergic asthma are poorly understood. We aimed to explore a novel lncRNA, LincR-protein phosphatase 2 regulatory subunit B' gamma (PPP2R5C), in Th2 differentiation in a mouse model of asthma.

methodsLincR-PPP2R5C from RNA-seq data of CD4

resultsLncR-PPP2R5C was significantly higher in CD4

conclusionsLincR-PPP2R5C regulated PPP2R5C expression and PP2A activity by forming an RNA-DNA triplex with the PPP2R5C promoter, leading to Th2 polarization in a mouse model of acute asthma. Our data presented the first definitive evidence of lncRNAs in the regulation of Th2 cells in asthma.

Indexed as

asthmainflammationLncRNAprotein phosphatase 2Th2 cells

Identifiers

PMID38262392
PMCPMC10823138
OpenAlexW4391061341

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.