Evidence map›Paper›PMID 38262379›Full record

ArticleMedical principles and practice : international journal of the Kuwait University, Health Science Centre2024

Clinical Benefits of Decreased Photo-Oxidative Stress on Human Embryo Development.

Krisztina Gödöny, Róbert Herczeg, Attila Gyenesei, Ákos Várnagy, Zoltán Bognár, Gábor L Kovács, Júlia Szekeres-Barthó, Péter Mauchart, Bernadett Nagy, János Erostyák and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Krisztina GödönyNational Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary.
Róbert HerczegNational Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary.
Attila GyeneseiNational Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary.
Ákos VárnagyNational Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary.
Zoltán BognárNational Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary.
Gábor L KovácsNational Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary.
Júlia Szekeres-BarthóNational Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary.
Péter MauchartNational Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary.
Bernadett NagyNational Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary.
János ErostyákSzentágothai Research Center, University of Pécs, Pécs, Hungary.
Kálmán KovácsNational Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary.
József BódisNational Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary.
University of Pecs · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveEarly embryonic development is characterized by rapid cell division and gene activation, making the embryo extremely sensitive to environmental influences. Light exposure can affect embryonic development through a direct toxic effect on the embryo via the generation of reactive oxygen species. In a previous study, we demonstrated the positive effect of improved light-protected embryo culture conditions implemented in our laboratory. This study aimed to investigate the changes in human embryo development under light protection during the conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). MATERIALS AND

methodsWe tested the potential beneficial effect of light filters to reduce the risk of toxic effects of light. IVF outcomes were compared between two experimental conditions, light protection with red light filters versus no light protection as a control.

resultsBlastocyst development rate in IVF was significantly higher in the light-protected group than in the group treated under conventional conditions (46.6 vs. 26.7%). In the case of ICSI, we obtained a similar result (44.5 vs. 31.6%). The rate of cryopreservation with at least one embryo was higher in the light-protected phase (32.8%) than in the conventionally manipulated phase (26.8%). The abortion rate was also significantly lower during the light-protected period in IVF, resulting in a higher live birth rate.

conclusionsThe implementation of light protection to reduce the embryotoxic wavelengths of light in IVF centers may improve the blastocyst development rate and embryo quality while maintaining embryo safety.

Indexed as

Embryo Culture TechniquesEmbryonic DevelopmentFertilization in VitroLightOxidative StressAdultBlastocystFemaleHumansMaleRetrospective StudiesSperm Injections, IntracytoplasmicAbortionBlastocystIntracytoplasmic sperm injectionIn vitro fertilizationLight protectionLive birth rate

Identifiers

PMID38262379
PMCPMC11095584
OpenAlexW4391127303

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.