ArticleNephron2024
Magnesium Decreases Urine Supersaturation but Not Calcium Oxalate Stone Formation in Genetic Hypercalciuric Stone-Forming Rats.
Article in Nephron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Magnesium and kidney stones: a concise narrative review.Clinical kidney journal · 2026Review
- Animal models for calcium oxalate kidney stone research.Zoological research · 2026Review
- Characterizing Chemokine Signaling Pathways and Hub Genes in Calcium Oxalate-Induced Kidney Stone Formation: Insights from Rodent Models.Biochemical genetics · 2026Article
- Serum calcium-magnesium-phosphate-potassium metabolic dysregulation in nephrolithiasis: predictive model development and mechanistic insights.Frontiers in physiology · 2026Article
- Metabolic consequences and tubular function after augmentation cystoplasty in children with neurogenic bladder.Journal of the Chinese Medical Association : JCMA · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
BACKGROUND/
aimsHypercalciuria is the most common identifiable risk factor predisposing to CaOx stone formation. Increased oral magnesium intake may lead to decreased CaOx stone formation by binding intestinal Ox leading to decreased absorption and/or binding urinary Ox to decrease urinary supersaturation. This study assessed the effect of oral magnesium on 24-h urine ion excretion, supersaturation, and kidney stone formation in a genetic hypercalciuric stone-forming (GHS) rat model of human idiopathic hypercalciuria.
methodsWhen fed the oxalate precursor, hydroxyproline, every GHS rat develops CaOx stones. The GHS rats, fed a normal calcium and phosphorus diet supplemented with hydroxyproline to induce CaOx, were divided into three groups of ten rats per group: control diet with 4.0 g/kg MgO, low MgO diet (0.5 g/kg), and high MgO diet (8 g/kg). At 6 weeks, 24-h urines were collected, and urine chemistry and supersaturation were determined. Stone formation was quantified.
resultsThe GHS rats fed the low and high Mg diets had a significant reduction and increase, respectively, in urinary Mg compared to those fed the control diet. Dietary Mg did not alter urine Ca excretion while the low Mg diet led to a significant fall in urinary Ox. Urine supersaturation with respect to CaOx was significantly increased with low Mg, whereas urine supersaturation was significantly decreased with high Mg. There was no effect of dietary Mg on stone formation within 6 weeks of treatment.
conclusionDietary magnesium decreases urine supersaturation but not CaOx stone formation in GHS rats.
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