Evidence map›Paper›PMID 38261827›Full record

ArticleActa pharmaceutica Sinica. B2024

Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties.

Dexiu Yan, Jemma Arakelyan, Teng Wan, Ritvik Raina, Tsz Ki Chan, Dohyun Ahn, Vladimir Kushnarev, Tsz Kiu Cheung, Ho Ching Chan, Inseo Choi and 13 more

Abstract read
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In one paragraph

Article in Acta pharmaceutica Sinica. B, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Dexiu YanDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.
Jemma ArakelyanDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.
Teng WanDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.
Ritvik RainaiGEM Team "VarieCure", City University of Hong Kong, Hong Kong SAR, China.
Tsz Ki ChanDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.
Dohyun AhnDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.
Vladimir KushnarevDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.
Tsz Kiu CheungDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.
Ho Ching ChanDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.
Inseo ChoiDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.
Pui Yi HoDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.
Feijun HuDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.
Yujeong KimDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.
Hill Lam LauDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.
Ying Lo LawDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.
Chi Seng LeungDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.
Chun Yin TongDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.
Kai Kap WongDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.
Wing Lam YimDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.
Nikolay S KarnaukhovMoscow Clinical Research Center Named After A.S. Loginov, Moscow 111123, Russian Federation.
Richard Y C KongDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.
Maria V BabakDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.
Yudai MatsudaDepartment of Chemistry, City University of Hong Kong, Hong Kong SAR, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin (

Indexed as

Animal studiesAnticancer propertiesBiosynthesisNatural productsSesterterpenoidsSynthetic biologyTerpene synthasesVariecolin

Identifiers

PMID38261827
PMCPMC10793096

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.