Evidence map›Paper›PMID 38261662›Full record

ArticleAutophagy2024

PRMT-7/PRMT7 activates HLH-30/TFEB to guard plasma membrane integrity compromised by bacterial pore-forming toxins.

Hui-Chen Hsieh, I-Hsiang Huang, Shao-Wen Chang, Po-Lin Chen, Yu-Cheng Su, Shuying Wang, Wei-Jiun Tsai, Ping-Hung Chen, Raffi V Aroian, Chang-Shi Chen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Hui-Chen HsiehDepartment of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
I-Hsiang HuangDepartment of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Shao-Wen ChangDepartment of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Po-Lin ChenDepartment of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID 0000-0002-4015-1052
Yu-Cheng SuInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Shuying WangInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID 0000-0003-3339-8070
Wei-Jiun TsaiInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Ping-Hung ChenInstitute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.ORCID 0000-0002-7156-0510
Raffi V AroianProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-9741-3834
Chang-Shi ChenDepartment of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID 0000-0002-8201-3635
National Cheng Kung University · TWNational Taiwan University · TWUniversity of Massachusetts Chan Medical School · US

Funding

Function/optimization of a nematicidal Cry toxin arsenalR01AI056189 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RAFFI V AROIAN · 2005 to 2026
$11.0M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIAID NIH HHS R01 AI056189NIH HHS P40 OD010440
6 · The paper itself

Abstract

Bacterial pore-forming toxins (PFTs) that disrupt host plasma membrane integrity (PMI) significantly contribute to the virulence of various pathogens. However, how host cells protect PMI in response to PFT perforation

Indexed as

Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsCaenorhabditis elegans ProteinsCell MembraneProtein-Arginine N-MethyltransferasesAnimalsBacterial ToxinsBasic Helix-Loop-Helix ProteinsCaenorhabditis elegansHEK293 CellsHumansMethylationBacterial ToxinsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBasic Helix-Loop-Helix ProteinsCaenorhabditis elegans ProteinsHLH-30 protein, C elegansPRMT7 protein, humanProtein-Arginine N-MethyltransferasesTFEB protein, humanIntrinsic cellular defense (INCED)plasma membrane integrity (PMI)pore-forming toxin (PFT)protein arginine methyltransferase-7 (PRMT7/PRMT-7)transcription factor EB (TFEB/HLH-30)

Identifiers

PMID38261662
PMCPMC11210913
OpenAlexW4391131002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.