Evidence map›Paper›PMID 38261611›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Tracking the role of Aire in immune tolerance to the eye with a TCR transgenic mouse model.

Mianmian Yin, Jennifer A Smith, Marissa Chou, Jackie Chan, Yingyos Jittayasothorn, Douglas B Gould, Rachel R Caspi, Mark S Anderson, Anthony L DeFranco

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Comparative models of uveitis.Eye (London, England) · 2025
    Review
  6. Tracking the role of Aire in immune tolerance to the eye with a TCR transgenic mouse model.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mianmian YinDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143.ORCID 0000-0001-5573-8991
Jennifer A SmithDiabetes Center, University of California, San Francisco, San Francisco, CA 94143.
Marissa ChouDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143.
Jackie ChanDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143.
Yingyos JittayasothornLaboratory of Immunology, National Eye Institute, NIH, Bethesda, MD 20892-1857.ORCID 0000-0001-6977-2728
Douglas B GouldDepartment of Ophthalmology, Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94143.ORCID 0000-0001-5127-5328
Rachel R CaspiLaboratory of Immunology, National Eye Institute, NIH, Bethesda, MD 20892-1857.ORCID 0000-0002-7140-7671
Mark S AndersonDiabetes Center, University of California, San Francisco, San Francisco, CA 94143.
Anthony L DeFrancoDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143.
University of California, San Francisco · USNational Eye Institute · US

Funding

Genetic, Cellular and Molecular Mechanisms in Autoimmunity to RetinaZIAEY000184 · NEI · NATIONAL EYE INSTITUTE · PI CASPI, RACHEL R. · 2009 to 2025
$51.7M
Medical Scientist Training Program (T32 NRSA Training Grant)T32GM141323 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Aimee Kao · 2021 to 2026
$10.5M
Organ-specific autoimmunity resulting from two genetic defects in toleranceR01AI138479 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEFRANCO, ANTHONY L · 2018 to 2022
$2.0M
NIAID NIH HHS R01 AI138479NIGMS NIH HHS T32 GM141323NIH HHS AI138479
6 · The paper itself

Abstract

Roughly one-half of mice with partial defects in two immune tolerance pathways (Aire

Indexed as

Antigen PresentationReceptors, Antigen, T-CellAIRE ProteinAnimalsAutoantigensDisease Models, AnimalMiceMice, Inbred StrainsMice, TransgenicAIRE ProteinAire protein, mouseAutoantigensReceptors, Antigen, T-CellAireautoimmuneIRBPnegative selectionuveitis

Identifiers

PMID38261611
PMCPMC10835137
OpenAlexW4391131129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.