Evidence map›Paper›PMID 38261520›Full record

ArticleInhalation toxicology2024

Lysosomal BK channels facilitate silica-induced inflammation in macrophages.

Rebekah L Kendall, Andrij Holian

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inhalation toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rebekah L KendallCenter for Environmental Health Sciences, University of Montana, Missoula, MT, USA.ORCID 0000-0001-5357-7717
Andrij HolianCenter for Environmental Health Sciences, University of Montana, Missoula, MT, USA.
Center for Environmental Health · US

Funding

Molecular Histology and Fluorescent ImagingP30GM103338 · NIGMS · UNIVERSITY OF MONTANA · PI MORANDI, MARIA T. · 2013 to 2017
$5.6M
Lysosomal BK channel regulates cSiO2-induced macrophage inflammationR21ES033511 · NIEHS · UNIVERSITY OF MONTANA · PI HOLIAN, ANDRIJ · 2022 to 2023
$407k
BK potassium channel activity in cSiO2-induced lysosome membrane permeability and inflammationF31ES033562 · NIEHS · UNIVERSITY OF MONTANA · PI KENDALL, REBEKAH · 2021 to 2022
$77k
NIEHS NIH HHS F31 ES033562NIEHS NIH HHS R21 ES033511NIGMS NIH HHS P30 GM103338
6 · The paper itself

Abstract

backgroundLysosomal ion channels are proposed therapeutic targets for a number of diseases, including those driven by NLRP3 inflammasome-mediated inflammation. Here, the specific role of the lysosomal big conductance Ca

methodsMurine macrophages were exposed

resultsPAX pretreatment significantly attenuated silica-induced cell death and IL-1β release. PAX caused an increase in lysosomal pH and decrease in lysosomal proteolytic activity. PAX also caused a significant accumulation of lysosomal cholesterol. BK channel activators NS11021 and NS1619 increased silica-induced cell death and IL-1β release. BK channel activation also caused a decrease in lysosomal pH and increase in lysosomal proteolytic function as well as a decrease in cholesterol accumulation.

conclusionTaken together, these results demonstrate that inhibiting lysosomal BK channel activity with PAX effectively reduced silica-induced cell death and IL-1β release. Blocking cytosolic K

Indexed as

Large-Conductance Calcium-Activated Potassium ChannelsNLR Family, Pyrin Domain-Containing 3 ProteinTetrazolesAnimalsCholesterolInflammasomesInflammationLysosomesMacrophagesMiceSilicon DioxideThiourea1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(1H-tetrazol-5-yl)phenyl)thioureaCholesterolInflammasomesLarge-Conductance Calcium-Activated Potassium ChannelsNLR Family, Pyrin Domain-Containing 3 ProteinSilicon DioxideTetrazolesThioureacholesterolinflammationion channelsLMPlysosomeMacrophagesilica

Identifiers

PMID38261520
PMCPMC11080613
OpenAlexW4391132170

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.